Abstract: Interleukin 32(IL-32) is a recently discovered cytokine. It is mainly secretes by the T cells, natural killer cells, epithelial cells, and blood monocytes. IL-32 not only has specific binding-proteinase,but also has a special coordinary function to synergize with muraryl dipeptide and nucleotide oligomerization domain (NOD).It has two paths for the signal transduction. Consequently, IL-32 exhibits many properties of proinflammatory cytokines and many biological functions.So it correlates with many diseases .Those characteres of IL-32 is significant to cure inflammatory disease. Thus, IL-32 plays a critical role in therapy inflammatory disease. So it has become more necessary to learn about the background and the current situation of IL-32. To summarize, this essay epitomizes the IL-32’s sources,binding-protein, structure of nucleic acid , signal transduction and synergism, emphasizes on biological function and associativity with diseases.