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中国农学通报

中国农学通报 ›› 2011, Vol. 27 ›› Issue (11): 43-45.

所属专题： 生物技术； 畜牧兽医

• 畜牧 动物医学 蚕 蜂 • 上一篇    下一篇

喹乙醇对小鼠血清抗氧化酶系活性的影响

戚凤奎 尹荣兰 尹荣焕 刘丽霞   

  • 收稿日期:2010-12-10 修回日期:2011-02-18 出版日期:2011-05-15 发布日期:2011-05-15
  • 基金资助:

    喹乙醇的食品安全性遗传毒理学评价及其蓄积毒性的机理研究。

Effect of Olaquindox on serum antioxidation activity of enzymes in mice

  • Received:2010-12-10 Revised:2011-02-18 Online:2011-05-15 Published:2011-05-15

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摘要：

摘要：按毒理学方法给小鼠灌喂不同剂量喹乙醇，探讨喹乙醇对小鼠血清抗氧化功能的影响。结果表明：喹乙醇对机体抗氧化功能的影响显著。低剂量会增强小鼠血清中的T-AOC，而高剂量则会产生一定的抑制作用。高剂量喹乙醇会使血清中SOD和GSH-Px的活力升高，MDA含量下降，说明喹乙醇引起动物机体抗氧化能力的降低应该是由GSH-Px和SOD以外的其他抗氧化因素来控制的，这些抗氧化因素不但中和了SOD和GSH-Px被诱导后的活力效应，而且明显降低了机体的抗氧化水平。

关键词: 锑矿区, 锑矿区

Abstract:

Abstract: Based on the method of toxicology, mice were administered with different dosage olaquindox by intragastric administration in order to investigate the effect of olaquindox on function of serum antioxidation in mice. The results were as follows. Olaquindox had a significant effect on the function of organism antioxidation. Low doses of olqquindox can increase the serum T-AOC in mice, and the high doses can produce a certain Inhibition. Olaquindox with high dose made the activity SOD and GSH-Px of antioxidase system rise, content of MDA and T-AOC lower, suggesting that olaquindox caused the decrease of antioxidation capacity by the regulation of other than GSH-Px and SOD. These antioxidation factors might not only eliminate the activity effect of GSH-Px and SOD, but also reduced significantly the body's antioxidant levels.