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中国农学通报

中国农学通报 ›› 2012, Vol. 28 ›› Issue (35): 69-74.

所属专题： 水产渔业

• 水产 渔业 • 上一篇    下一篇

微囊藻毒素对鱼类的毒性效应及其作用机理研究进展

明俊超 姜海洲 袁新华   

  • 收稿日期:2012-04-16 修回日期:2012-05-29 出版日期:2012-12-15 发布日期:2012-12-15

A Review of Microcystin: Toxic Effects and Mechanisms in Exposed Fish

  • Received:2012-04-16 Revised:2012-05-29 Online:2012-12-15 Published:2012-12-15

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摘要：

微囊藻毒素(Microcystin，MC)对鱼类毒性效应及影响机制的研究已成为当前环境科学研究中的一个热点。本研究综述了MC对鱼类的毒性效应、MC构象和毒性的关系、进入鱼体的途径以及可能存在的2种毒性机制等，并对MC毒性的预防和治疗进行了展望。对国内外大量的MC毒理研究的比较发现：MC进入鱼体的途径可能有多条，但主要是通过消化道的吸收。MC可能通过2条通路来表现其毒性影响，即通过氧化胁迫产生过多的活性氧(ROS)对蛋白磷酸酶起到第二信使作用，或者与其产生的ROS共同对蛋白磷酸酶起到抑制作用。MC对鱼类的氧化胁迫机制涉及到特异性抗氧化和内源性抗氧化两方面，这方面的研究将为预防和治疗MC的毒性作用提供理论基础。

关键词: 水资源生态承载力, 水资源生态承载力

Abstract:

Toxic effect and mechanism of Microcystin (MC) on fish had became a hotspot in environment toxicology. This review included the effects of fish exposed to MC; the relationship between structure and toxic effect; the routs that MC would be absorbed by fish; two kinds of potential mechanisms that MC induced toxic effect on fish. Enormous toxic researched on MC have been done to indicate that intestinal tract might be the most potential rout that MC was absorbed by fish; MC induced oxidative stress on fish, surplus reactive oxygen species (ROS), as a second messenger, and/or MC could inhibited protein phosphatases 1 and 2A which have important role of cell signaling. Special anti-oxidation and endogenesis anti-oxidation were involved by novel research aspects of mechanism on oxidative stress.