Abstract: The effects of compounds of Astragalus polysaccharide (APS) and profitable microbe (PM) on growth performance and immune function of chicks were studied. 240 Hy-Line chicks were randomly divided into 4 groups with 6 replicates (10 chicks per replicate). The experiment last 6 weeks and feed and water were provided freely. The basic diet of the 4 groups was the same and treatments were as follows: control (no APS and no PM), 220mg/kg APS, 4×107cfu/g PM and 220mg/kg APS+4×107cfu/g PM. In the end of every week of the trial, chicks and forage consumption were weighed and feed/growth were calculated; In the end of third and sixth week, blood was sampled in the heart and then chicks were slaughtered to weigh Bursa of Fabricius and Spleen. The results showed: All of APS, PM and the compounds could significantly increase Average Growth of Each Week (p<0.05), decrease forage consumption (p<0.05), lower feed/growth (the decrease was respectively 13.96%, 15.26% and 12.34%, p<0.05). But it did not show that there is no significant difference of growth performance between PM+APS group and APS group or PM group (p>0.05). Compared to the control group, serum total protein of the trial groups are higher (p<0.05), but serum glucose is lower (p<0.05). The index of Bursa of Fabricius and Spleen of APS+PM group are both significantly higher than the others (p<0.05). Serum antibody titer to Newcastle disease vaccine of the trial groups are higher than the control group (p<0.05), and the effect of APS+PM group is the best remarkable.