Abstract: A tissue check of liver, spleen, uterus, epidermoid c. skin of Panda “Dan-Dan” which was the only one panda reared by manpower whose color was brown and white in the world, was conducted. The light microscopical observation showed that the main histopathological changes were expandable sinusoid of liver and spleen, along with vacuolation in cellular plasma, degeneration and necrosis of liver cell. Many erythrocyte and kupffer cells were seen in sinusoid of liver and spleen, along with many yellow and brown irons contained blood grains. Lymphocyte increased in lymph nodule of white pulp. Lamina propria of uterus was composed of connective tissue, which abound with blood vessel. Spinosumocyte of epidermoid c. skin growed in an untypical form, while spinosumocyte of mouth skin did not grow.