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中国农学通报 ›› 2014, Vol. 30 ›› Issue (21): 1-8.doi: 10.11924/j.issn.1000-6850.2014-0697

所属专题: 生物技术

• 农学 农业基础科学 •    下一篇

组蛋白去乙酰化酶(HDACs)及其调控的研究进展

钟理   

  • 收稿日期:2014-03-15 修回日期:2014-05-23 出版日期:2014-07-25 发布日期:2014-07-25
  • 基金资助:
    贵州省科技厅科学技术基金资助项目“矮生高羊茅优良种质挖掘与利用”(黔科合J字[2009]2133号),“贵州高羊茅内生真菌资源及其多样性研究”(黔科合J字[2012]2202号);贵州省科技攻关计划项目“节能高羊茅航空诱变种质创新与新品种选育”(黔科合NY字[2010]3044号);贵州省科技成果推广计划项目“国审牧草新品种水城高羊茅配套技术应用推广”(黔科合成字[2013]5083)。

The Progress of Histone Deacetylase and Its Regulation

  • Received:2014-03-15 Revised:2014-05-23 Online:2014-07-25 Published:2014-07-25

摘要: 组蛋白乙酰化修饰是表观遗传研究的重要内容,其行使去乙酰化功能的去乙酰化酶更是临床肿瘤抑制剂研究开发的热点。通过动物和酵母的深入研究,组蛋白去乙酰化酶广泛的参与了生物生长发育的调控。介于组蛋白乙酰化修饰在植物上的相关研究较少,文章借鉴动物和酵母的研究结果,归纳了其作用方式,通过氨基酸序列相似性、蛋白保守结构域分析,分析了植物去乙酰化酶可能行使的功能,得出以下结论:从组蛋白去乙酰化酶(HDACs)对对激素及非生物胁迫的响应来看,HDACs广泛的参与了植物生长发育的调控;酵母、动植物HDACs蛋白保守结构域分布有所不同,表明植物HDACs可能存在与酵母、动物不同的功能和调控方式;植物也存在非组蛋白乙酰化修饰,但其发挥功能的酶还需要进一步确认。

关键词: 超富集植物, 超富集植物

Abstract: Histone deacetylation played an important role in epigenetic, and histone deacetylase, which acted in concert with histone acetyltransferase, was a target to develop new medicine of tumor inhibitor. This paper reviewed recent findings of histone deacetylase in animal and yeast, and analyzed their homology of amino acid sequence and conserved domains with Arabidopsis thaliana, summarized their function of regulation, aimed to predict its function in plant development. It is concluded that, from its response to hormone stimulation and abiotic stress, HDACs widely participates in plants’development. The function of Plant’s HDACs may differ from animal and yeast because of their different conserved domains distribution in protein sequences. Although HDACs’function in Non-histone acetylation is still unknown, Non-histone acetylation actually exists.