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中国农学通报 ›› 2005, Vol. 21 ›› Issue (11): 25-25.

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飞机草的急性LD50测定和亚急性毒性研究

陈进军,李淑红,许璧煜   

  • 出版日期:2005-11-05 发布日期:2005-11-05

Studies on Acute LD50 and Subacute Toxicities of Eupatorium odoratum

Chen Jinjun, Li Shuhong, Xu Biyu   

  • Online:2005-11-05 Published:2005-11-05

摘要: 给昆明种雌性小白鼠经口灌服飞机草水提物,用改良寇氏法测定了飞机草全草的急性LD50;另取一批小白鼠,每隔3d分别用浓度为5g/ml、2.5g/ml、1.25g/ml和0.625g/ml的飞机草水提物经口灌服一次,共灌服5次,进行试验期为35d的飞机草亚急性毒性试验。结果发现,飞机草全草水提物对昆明种雌性小白鼠的急性LD50为227091.02mg/kg,95%可信限为227090.96~227091.07 mg/kg,即飞机草水提物对昆明种雌性小白鼠实际无毒。但飞机草具有亚急性毒性作用,供试小白鼠出现中毒体

Abstract: A range of female Kunming mice were orally administered with decoction of Eupatorium odoratum Linn to measure the acute median lethal dose (LD50) of E. odoratum. And another batch of Kunming mice were orally administered decoction of E. odoratum at dosages