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中国农学通报 ›› 2024, Vol. 40 ›› Issue (12): 80-84.doi: 10.11924/j.issn.1000-6850.casb2023-0073

• 生物科学 • 上一篇    下一篇

铜绿假单胞菌的耐药性和耐药机制

陈宇(), 王林, 秦上尚   

  1. 河南农业大学动物医学院,郑州 450046
  • 收稿日期:2023-01-29 修回日期:2023-05-15 出版日期:2024-04-25 发布日期:2024-04-22
  • 作者简介:

    陈宇,女,1983年出生,河南许昌人,实验师,硕士,主要从事兽医药理方面研究。通信地址:450046 河南省郑州市郑东新区平安大道218号动物医学院,Tel:0371-56990180,E-mail:

Pseudomonas aeruginosa: Drug Resistance and Mechanism

CHEN Yu(), WANG Lin, QIN Shangshang   

  1. College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046
  • Received:2023-01-29 Revised:2023-05-15 Published:2024-04-25 Online:2024-04-22

摘要:

铜绿假单胞菌是一种多重耐药性病原体,其感染在临床上构成了重大挑战。本文归纳综述了铜绿假单胞菌的固有性耐药、获得性耐药和适应性耐药机制,旨在为临床预防和治疗提供新的视角和方法。铜绿假单胞菌之所以能够抵御多数抗生素攻击,主要是依赖其高水平的固有性和获得性耐药性。固有耐药性涉及多种药物外排泵系统、低渗透性的外膜以及天然存在的抗生素降解酶等。获得性耐药性则是通过基因突变、接合转移以及水平基因转移等途径实现。适应性耐药性则与生物膜的形成和群体感应系统的调控紧密相关。文章通过分析这些不同耐药性的特点和发展趋势,探讨目前的治疗方法,指出铜绿假单胞菌耐药现象是多机制共同作用的结果,而非单一因素所致。鉴于此,未来治疗铜绿假单胞菌感染的有效策略可能需要结合传统治疗方法与新治疗方法相结合的联合治疗手段,研究为开发针对铜绿假单胞菌的新型治疗方法提供了理论基础,并为临床治疗提供了新的思路。

关键词: 铜绿假单胞菌, 固有性耐药性, 获得性耐药性, 适应性耐药性, 耐药机制

Abstract:

In order to provide new treatment methods and strategies for clinical prevention and treatment of Pseudomonas aeruginosa infection, the inherent resistance, acquired resistance and adaptive resistance of Pseudomonas aeruginosa are summarized in this paper. With the mechanisms of different resistance, the characteristics, development trends and treatment methods of Pseudomonas aeruginosa resistance under different situations are also analyzed. This paper points out that Pseudomonas aeruginosa resistance mainly depends on its high level of inherent and acquired resistance, while its adaptive resistance mainly depends on the formation of biofilm mediation and quorum sensing. It is proposed that clinical Pseudomonas aeruginosa resistance is not the result of a single resistance. In all, the most effective treatment strategy in the future is to carry out combination therapy based on traditional treatment and new treatment.

Key words: Pseudomonas aeruginosa, inherent resistance, acquired resistance, adaptive resistance resistance, mechanisms