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中国农学通报

中国农学通报 ›› 2013, Vol. 29 ›› Issue (5): 37-41.doi: 10.11924/j.issn.1000-6850.2012-1689

所属专题： 畜牧兽医

• 畜牧 动物医学 蚕 蜂 • 上一篇    下一篇

小花棘豆黄酮对小鼠抗衰老作用的研究

王帅 蒋慧 席琳乔 陈根元 张玲 马春晖   

  • 收稿日期:2012-05-03 修回日期:2012-06-11 出版日期:2013-02-15 发布日期:2013-02-15
  • 基金资助:
    “十二五”国家科技支撑计划“西北和青藏地区优质牧草丰产栽培及草畜耦合技术集成与产业化示范”(2011BA017B05)；国家自然科学基金“新疆小花棘豆SW人工抗原合成及免疫学效应研究”(31160497)；新疆生产建设兵团博士基金专项“新疆醉马草（小花棘豆）毒性成分新型疫苗的研究”(2008JC07)；新疆生产建设兵团塔里木畜牧科技重点实验室开放课题“抗苦马豆素抗体的制备及临床应用研究”(HS201207)。

Study on the Anti-aging Effect of Flavonoid from Oxytropis glabra DC on Mice

  • Received:2012-05-03 Revised:2012-06-11 Online:2013-02-15 Published:2013-02-15

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摘要： 为探讨新疆小花棘豆黄酮对衰老模型小鼠的抗衰老作用。用D-半乳糖制备衰老小鼠模型，然后分别以100、200、300 mg/(kg·d)剂量的小花棘豆黄酮灌胃，观察其对血清、肝脏和脑组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)的活性及丙二醛(MDA)和脂褐素(LPO)含量，以及对小鼠缺氧存活时间及游泳时间的影响。结果表明：小花棘豆黄酮能不同程度增加血清和组织中SOD、GSH-Px、CAT的活力，极显著降低MDA和LPO含量。高剂量的小花棘豆黄酮还能极显著延长小鼠在缺氧条件下的存活时间和常温游泳时间。小花棘豆黄酮具有较好的抗衰老作用。

关键词: c-fos, c-fos

Abstract: The purpose of this project was to study the anti-aging activity on flavonoid from Oxytropis glabra DC. To observe the effect on activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT), the content of malondialdehyde (MDA) and lipofuscim (LPO) in serum, liver and brain, the survival time under hypoxic condition and swimming time of mice with senile model caused by D-galatose and meanwhile administered with flavonoid from Oxytropis glabra DC of 100, 200, 300 mg/(kg·d) orally. The results showed that the activity of SOD, GSH-Px and CAT in serum and tissue were increased which mice fed flavonoid from Oxytropis glabra DC, the content of MDA and LPO dropped significantly. Meanwhile, the survival time under hypoxic condition and the swimming time at normal temperature were prolonged significantly. It was found that flavonoid from Oxytropis glabra DC had the obvious effect on anti-senility.