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中国农学通报

中国农学通报 ›› 2013, Vol. 29 ›› Issue (15): 135-141.doi: 10.11924/j.issn.1000-6850.2012-3666

所属专题： 生物技术

• 生物技术科学 • 上一篇    下一篇

载脂蛋白B RNA编辑机制概述

刘树涛 李慧萍 齐庆远   

  • 收稿日期:2012-11-09 修回日期:2012-12-09 出版日期:2013-05-25 发布日期:2013-05-25
  • 基金资助:
    浙江省公益计划项目

Overview of Apolipoprotein B RNA Editing Mechanism

  • Received:2012-11-09 Revised:2012-12-09 Online:2013-05-25 Published:2013-05-25

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摘要： 载脂蛋白B (apoB)是负责脂类转运的脂蛋白中的蛋白组成部分，在人体内主要以apoB-100和apoB-48两种形式存在。apoB-48是apoB-100 mRNA转录后经RNA编辑产生的。包含apoB-48的脂蛋白不会变成致动脉粥样硬化的低密度脂蛋白。编辑过程涉及一系列蛋白质对单个碱基进行精确的脱氨基修饰，受多种因素的调节。这些蛋白质的精确组成及各自在编辑过程中的作用尚不清楚。对apoB mRNA编辑机制的理解有助于为脂蛋白相关疾病治疗提供理论依据。

关键词: 适宜指标, 适宜指标

Abstract: Apolipoprotein B (apoB), an essential structural component of lipoproteins responsible for lipid transportation, circulates in two forms in human, apoB-100 and apoB-48. The generation of apoB-48 is due to the apoB-100 mRNA editing. ApoB-48-containing lipoproteins cannot be converted into the atherogenic low dendity lipoproteins. ApoB RNA editing involves precise deamination of a single nucleotide by a coordinated protein, which is regulated by many elements. Accurate components in the editosome and their role remain unclear. Understanding of the mechanism responsible for apoB mRNA editing will provide the theoretical basis for lipoprotein-related diseases.