氯虫苯甲酰胺的残留降解与检测分析研究进展

doi:10.11924/j.issn.1000-6850.2014-1821

摘要/Abstract

摘要： 氯虫苯甲酰胺是作用于昆虫鱼尼丁受体的新型邻甲酰氨基苯甲酰胺类杀虫剂，具有杀虫活性高、杀虫谱广、持效期长、害虫不易产生抗性、对非靶标生物安全、与常规药剂无交互抗性等特性，被广泛应用于水稻、蔬菜等农作物上鳞翅目害虫的防治。为了解氯虫苯甲酰胺在作物和环境中的降解情况及残留分析方法，本研究介绍了氯虫苯甲酰胺的理化特性、作用机理、作用特点与抗药性，总结了它在作物、土壤和水体中的降解研究现状，概述了其残留物的提取、净化、分析原理和方法，并对今后的研究重点进行了展望。结果表明，氯虫苯甲酰胺是一种具有市场发展潜力的绿色环保杀虫剂，非常适合于害虫的抗性治理和综合治理。目前在各类样品基质中其残留物的检测分析主要采用高效液相色谱方法。田间试验结果表明，氯虫苯甲酰胺在作物上降解速度快、半衰期短，属于易降解类农药，按照推荐剂量正确施用，在作物上不会造成残留，但它在土壤中的持留期较长，长期使用可能存在累积残留风险。此外，该杀虫剂对家蚕毒性高，在蚕区应谨慎使用。同时，大量、频繁地使用该杀虫剂已经发现有害虫产生了抗药性。

关键词: 综合得分, 综合得分

Abstract: Chlorantraniliprole is a new anthranilic diamide insecticide acting with high efficacy on insect ryanodine receptors. Because of its excellent insecticidal activity, broad insecticidal spectrum, long lasting crop protection, difficult resistance to insects, non-target organisms safety and no cross-resistance to other existing insecticides, it is becoming widely used for pest control in agriculture, especially lepidopteran pests of rice and vegetable crops. To understand the degradation of chlorantraniliprole and its residue analytical methods in agricultural and environmental samples, the physical

刘腾飞,杨代凤,邓金花,董明辉. 氯虫苯甲酰胺的残留降解与检测分析研究进展[J]. 中国农学通报, 2015, 31(3): 221-228.

参考文献

[1] Dinter A, Brugger K, Bassi A, et al. Chlorantraniliprole(DPX-E2Y45,Rynaxypyr?)(Coragen?20SC and Altacor?35WG)-a Novel DuPont Anthranilic Diamide Insecticide-demonstrating Low Toxicity and Low Risk for Beneficial Insects and Predatory Mites[J]. IOBC WPRSBulletin,2008(35):128-135.
[2] 李永平,王强,龚玉琴.甲胺磷等5种高毒农药替代品种及其使用技术[J].中国植保导刊,2009,29(9):44-46.
[3] 鸥晓明,唐德秀,林雪梅.新型邻甲酰胺基苯甲酰胺类农药氯虫苯甲酰胺的研究概述[J].世界农药,2007,29(5):6-10.
[4] 张志东,李春,刘勇,等.氯虫苯甲酰胺200SC对水稻的控害作用及对产量的影响[J].西南师范大学学报(自然科学版),2011,36(5):109-114.
[5] 彭永武,柴宝山,李慧超,等.新法合成杀虫剂氯虫酰胺[J].研发前沿,2009,17(6):19-20.
[6] 王艳军,张大永,吴晓明.氯虫苯甲酰胺的合成[J].农药,2010,49(3):170-173.
[7] 陈一芬,刘爱霞,冀亚飞.氯虫酰胺的合成[J].化学试剂,2010,32(10):937-938,954.
[8] Lahm G P, Stevenson T M, Selby T P, et al. RynaxypyrTM: a New Insecticidal Anthranilic Diamide that Acts as a Potent and Selective Ryanodine Receptor Activator[J]. Bioorganic and Medicinal Chemistry Letters,2007,17(22):6274-6279.
[9] Liu G Y, Ju X L, Cheng J, et al. 3D-QSAR Studies of Insecticidal Anthranilic Diamides as Ryanodine Receptor Activators Using CoMFA, CoMSIA and DISCOtech[J]. Chemosphere,2010(78):300-306.
[10] Koppenh?fer A M, Fuzy E M. Effect of the Anthranilic Diamide Insecticide, Chlorantraniliprole, on Heterorhabditis Bacteriophora (Rhabditida: Heterorhabditidae) Efficacy Against White Grubs (Coleoptera: Scarabaeidae) [J].Biological Control,2008(45):93-102.
[11] Cao G C, Lu Q, Zhang L L, et al. Toxicity of Chlorantraniliprole to Cry1Ac-Susceptible and Resistant Strains of Helicoverpa armigera[J].Pesticide Biochemistry and Physiology,2010,98(1):99-103.
[12] 张武军,张辉,张伟,等.18.5%氯虫苯甲酰胺悬浮剂防治水稻二化螟药效试验[J].农药,2009,48(3):230-232.
[14] 陈时健,李春曦,成玮,等.0.4%氯虫苯甲酰胺颗粒剂防治水稻纵卷叶螟的效果评价[J].世界农药,2012,34(5):43-46.
[15] 于永浩,龙秀珍,曾宪儒,等.200g/L氯虫苯甲酰胺悬浮剂对甘蔗螟虫的防效及对甘蔗产量的影响[J].安徽农业科学, 2013,41(34):13230-13231,13233.
[16] 刘立峰,莫小荣,徐法三.氯虫苯甲酰胺+噻虫嗪防治水稻早期虫害的效果[J].浙江农业科学,2013(7):837-838.
[17] 王义生,刘煜财,王喜军,等.40%氯虫苯甲酰胺?噻虫嗪对吉林省玉米螟的药效试验与安全性[J].吉林农业科学,2014,39(2):54-56.
[18] 王广成,吴春先,高立明,等.氯虫苯甲酰胺悬浮剂的高效液相色谱分析[J].农药,2009,48(4):267-269.
[19] 亢晓冬,孙霞,沈礼,等.氯虫苯甲酰胺的高效液相色谱分析方法研究[J].浙江化工,2010,41(4):31-32.
[20] 陈小军,王萌,范淑琴,等.QuEChERS前处理结合HPLC-MS/MS法分析氯虫苯甲酰胺在甘蓝和土壤中的残留[J].中国农业科学,2012,45(13):2636-2647.
[21] Grant J, Rodgers C A, Chickering C D,et al. Determination of Chlorantraniliprole Residues in Crops by Liquid Chromatography Coupled with Atmospheric Pressure Chemical Ionization Mass Spectrometry/Mass Spectrometry[J].Journal of AOAC International,2010,93(4):1293-1301.
[22] Malhat F M. Determination of Chlorantraniliprole Residues in Grape by High-Performance Liquid Chromatography[J].Food Anal Methods, 2012,(5):1492-1496.
[23] DuPont. Rynaxypyr Technical Bulletin[R].2007-12-27.
[24] 杨桂秋,童怡春,杨辉武,等.新型杀虫剂氯虫苯甲酰胺研究概述[J].世界农药,2012,34(1):31-34.
[25] 吴群.氯虫苯甲酰胺在液相中的光化学降解研究[D].安徽农业大学,2012
[26] 付启明,欧晓明,刘红玉,等.新农药氯虫酰胺在醇液中的光解[J].生态环境学报,2010,19(3):532-536.
[27] Narahashi T. Neuronal Ion Channels as the Target Sites of Insecticides[J].Pharmacol Toxicol,1996(78):1-14.
[28] Ikeda T, Zhao X, Nagata K, et al . Fipronil Modulation ofγ-aminobutyric Acid Receptors in Rat Dorsal Root Ganglion Neurons[J]. J Pharmacol Exp Ther,2001(296):914-921.
[29] Matsuda K, Buckingham S D, Freeman J C, et al. Effects of the α Subunit on Imidacloprid Sensitivity of Recombinant Nicotinic Acetylcholine Receptors [J].British J Pharmacology,1998(123):518-524.
[30] Ogawa Y. Role of Ryanodine Receptors[J]. Critical Reviews in Biochemistry and Molecular Biology,1994,29(4):229-274.
[31] Berridge M J, Lipp P, Bootman M D. TheVersatility and Universality of Calcium Signalling [J].Nat Rev Mol Cell Biol,2000,1(1):11-21.
[32] Cordova D, Benner E, Sacher M, et al. Anthranilic Diamides: a New Class of Insecticides With a Novel Mode of Action, Ryanodine Receptor Activation[J].Pest Biochem Physiol,2006,84(3):196-214.
[33] Lahm G P, Cordova D, Barry J D. New and Selective Ryanodine Receptor Activators for Insect Control[J]. Bioorganic & Medicinal Chemistry, 2009,17(12):4127-4133.
[34] Hannig G T, Ziegler M, Marcon P G. Feeding Cessation Effects of Chlorantraniliprole, a New Anthranilic Diamide Insecticide, in Comparison With Several Insecticides in Distinct Chemical Classes and Mode-of-Action Groups[J]. Pest Manag Sci,2009,65(9):969-974.
[35] 张一宾.鱼尼汀受体及以其为靶标的杀虫剂的作用机理[J].世界农药,2007,29(4):1-6.
[36] 闫潇敏,宁斌科,王列平,等.新型邻酰胺基苯甲酰胺类杀虫剂氯虫苯甲酰胺的合成与应用[J].世界农药,2009,31(6):20-23.
[37] Ioriatti C, Anfora G, Angeli G, et al.Effects of Chlorantraniliprole on Eggs and Larvae of Lobesia botrana(Denis & Schiffermüller) (Lepidoptera: Tortricidae)[J]. Pest Management Science,2009,65(6):717-722.
[38] 马冲,路兴涛,刘震,等.氯虫苯甲酰胺、毒死蜱亚致死剂量对甜菜夜蛾生长发育和繁殖力的影响[J].植物保护,2012,38(4):38-41.
[39] 刘芳,奚本贵,包善微,等.氯虫苯甲酰胺对稻纵卷叶螟的防效及对稻田有益节肢动物的安全性评价[J].植物保护,2009,35(5):139-143.
[40] 徐广春,顾中言,徐德进,等.氯虫苯甲酰胺和噻虫胺对水稻的表观安伞性评价[J].农药,2009,48(10):752-754.
[41] 陈伟国,董瑞华,孙海燕,等.农用杀虫剂氯虫苯甲酰胺对家蚕的毒性研究[J].蚕业科学,2010,36(1):84-90.
[42] Wang X L, Wu Y D. High Levels of Resistance to Chlorantraniliprole Evolved in Field Populations of Plutella xylostella[J]. Journal of Economic Entomology,2012,105(3):739-1106.
[43] Sukonthabhirom S, Dumrongsak D, Jumroon S, et al. Update on DBM Diamide Resistance from Thailand: Causal Factors and Learnings[DB /OL].(2011-03-25)[2011-08-10].http: //www. irac- online. org/resources-2/document- library/#Posters.
[44] 胡珍娣,陈焕瑜,李振宇,等.华南小菜蛾田间种群对氯虫苯甲酰胺已产生严重抗性[J].广东农业科学,2012(1) :79-80,83.
[45] Resistance to Diamide Insecticides in Diamondback Moth, Plutella xylostella (Lepidoptera:Plutellidae) is Associated With a Mutation in the Membrane-Spanning Domain of the Ryanodine Receptor[J].
[46] Lai T C, Li J, Su J Y. Monitoring of Beet Armyworm Spodoptera exigua (Lepidoptera: Noctuidae) Resistance to Chlorantranilprole in China[J]. Pestic Biochem Physiol,2011,101(3):198-205.
[47] 牛芳.小菜蛾对氯虫苯甲酰胺的防御、代谢及抗性风险评估[D].山东:山东农业大学, 2011.
[48] 李瑞娟,于建垒,宋国春,等.氯虫苯甲酰胺在甘蓝和土壤中的残留及消解动态[J].生态环境学报,2011,20(4):663-667.
[49] Malhat F, Abdallah H, Hegazy I. Dissipation of Chlorantraniliprole in Tomato Fruits and Soil[J]. Bull Environ Contam Toxicol,2012(88):349-351
[50] 孟东升,郭强,翟军法,等.氯虫?噻虫嗪在芥蓝中的残留消解动态研究[J].中国植保导刊,2012,32(11):5-8.
[51] Kar A, Mandal K, Singh B. Environmental Fate of Chlorantraniliprole Residues on Cauliflower Using QuEChERS Ttechnique[J]. Environ Monit Assess,2013(185):1255-1263.
[52] 王思威,孙海滨,刘艳萍.氯虫苯甲酰胺颗粒剂在水稻环境中的残留行为与合理使用评价[J].农药,2013,52(12):899-902.
[53] 王廷廷,余向阳,沈燕,等.生物质炭施用对土壤中氯虫苯甲酰胺吸附及消解行为的影响[J].环境科学,2012,23(4):1339-1345.
[54] 王廷廷,余向阳,刘贤进,等.氯虫苯甲酰胺在5种土壤中的吸附和解吸特性[J].江苏农业学报,2012,28(1):204-209.
[55] Ramasubramanian T, Paramasivam M, Salin K P, et al. Dissipation Kinetics of Chlorantraniliprole in Soils of Sugarcane Ecosystem[J]. Bull Environ Contam Toxicol, 2012(89):1268-1271.
[56] Sharma N, Mandal K, Kumar R, et al. Persistence of Chlorantraniliprole Granule Formulation in Sugarcane Field Soil[J]. Environ Monit Assess,2014(186):2289-2295.
[57] Zhang J M, Chai W G, Wu Y L. Residues of Chlorantraniliprole in Rice Field Ecosystem[J]. Chemosphere, 2012(87):132-136.
[58] U S Environmental Protection Agency. Pesticide Fact Sheet: Chlorantraniliprole[R]. Washinton DC :U S EPA, 2008:11-14.
[59] 章虎,钱鸣蓉,李振,等.高效液相色谱-串联质谱快速测定稻米中氯虫苯甲酰胺残留[J].农药,2010,49(12):906-908.
[60] Xu P J, Ren Y, Zhou Z G, et al. Determination of Chlorantraniliprole in Vegetables, Fruits and Grains by SPE Clean-Up and LC-UV[J]. Chromatographia, 2010(72):763-766.
[61] 步海燕,欧晓明,马俊凯,等.高效液相色谱法测定水体中的氯虫苯甲酰胺残留量[J].光谱实验室,2008,25(6):1230-1234.
[62] 王学玲,孙克,张敏恒.氯虫苯甲酰胺分析方法述评[J].农药,2012,51(12):933-935.
[63] 钱鸣蓉,章虎,吴俐勤,等.高效液相色谱-串联质谱法测定蔬菜中氯虫苯甲酰胺和氟虫双酰胺残留[J].分析化学,2010,38(5):702-706.
[64] 孟海涛,艾连峰,徐牛生.在线净化液相色谱-串联质谱法测定蔬菜中噻虫嗪和氯虫苯甲酰胺的残留[J].环境化学,2014,33(2):369-371.
[65] 郭庆龙,崔淑华,刘靖靖,等.高效液相色谱-串联质谱法测定果蔬中6种新型杀虫剂残留[J].化学通报,2013,76(10):951-956.
[66] Cui Y L, Liu K C, Xu C, et al. Development of a Sensitive Monoclonal Antibody-Based Indirect Competitive Enzyme-Linked Immunosorbent Assay for AnalySing Chlorantraniliprole Residues[J]. Food Chemistry,2014(143):293-299.
[67] 陈意光,罗海英,罗东辉,等.食品中6种新型农药的超高效液相色谱-串联质谱法测定[J].江南大学学报(自然科学版),2013,12(2):227-223.
[68] 贺敏,朱晓丹,贾春虹,等.玉米中氯虫苯甲酰胺残留的超高效液相色谱分析方法[J].农药学学报,2013,15(5):597-600.