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中国农学通报

中国农学通报 ›› 2015, Vol. 31 ›› Issue (2): 62-66.doi: 10.11924/j.issn.1000-6850.2014-1712

所属专题： 畜牧兽医

• 畜牧 动物医学 蚕 蜂 • 上一篇    下一篇

刺山柑提取物对正常小鼠耳廓微循环的作用

包晓玮1,阎晓菲2,常永志1,李 霞2,孙正涛2   

  1. (1新疆农业大学食品科学与药学学院,乌鲁木齐 830052；2新疆农业大学科技学院,乌鲁木齐 830052）
  • 收稿日期:2014-06-17 修回日期:2014-10-29 接受日期:2014-10-30 出版日期:2015-03-19 发布日期:2015-03-19
  • 通讯作者: 包晓玮
  • 基金资助:
    新疆农业大学校前期课题“刺山柑提取物对大鼠微循环效果的研究”（XJAU201026）；新疆农业大学科技学院大学生创新项目“刺山柑提取物的药效学研究”（20110502）。

The Effects of the Extraction from Capparis Spinosa Lon Microcirculation of
Auricle in Normal Mice

Bao Xiaowei1, Yan Xiaofei2, Chang Yongzhi1, Li Xia2, Sun Zhengtao2   

  1. (1College of Food Science and Pharmacology, Xinjiang Agricultural University, Urumqi 830052;2Institute of Science and Technology Xinjiang Agricultural University, Urumqi 830052)
  • Received:2014-06-17 Revised:2014-10-29 Accepted:2014-10-30 Online:2015-03-19 Published:2015-03-19

摘要： 研究刺山柑提取物（CSE）对小鼠耳廓微循环的影响，为改善微循环障碍性疾病提供实验依据。将正常小鼠50只随机分为5组（空白对照组，阳性对照组，CSE 1.25、2.5、5 mg/(10g·天)组。每天给药一次，连续灌胃7天。用WX-6微循环显微仪分别于末次给药后六个时间点即0.5、1.0、1.5、2.0、2.5、3.0 h于给药前耳廓相同部位测量耳廓微循环微动脉、微静脉血管口径及毛细血管开放的数目。与空白组比较，CSE低、中、高剂量组能明显增加耳廓微血管管径及毛细血管开放数目（P<0.05），增强作用与 作用时间及剂量成正相关，以CSE高剂量更为显著。CSE对正常小鼠微循环具有改善作用。

关键词: 本溪山区, 本溪山区

Abstract: To investigate the effects of CSE on Microcirculation of Auricle in Normal Mice, and to provide the experimental basis to improve Microcirculation disorders. NIH mice were divided into five groups at random(contrast, positive contrast of APC(250 mg/(kg·d)),CSE(80 mg/(kg·d)), 160 mg/(kg·d), 320 mg/(kg·d). All were given drug by continuous lavage 7 days. The capillary vessal number, the diameter of thin vein and artery, the fiow velocity of thin artery was monitored by WX-6 microcirculation microscope test machine before and 0.5、1.0、1.5、2.0、2.5、3.0 h after administrating the drug. Compared with contrast group, the low, middle and high group can increase the diameter of auricle micro vein and auricle capillary open numbers(P<0.05，P<0.01),the test item was increased and time and dosage dose related, the high was more obvious. CSE can improve the Microcirculation of Auricle in Normal Mice.