雌二醇对哺乳动物子宫内膜血管生成调控的研究进展

doi:10.11924/j.issn.1000-6850.casb2020-0251

中国农学通报 ›› 2021, Vol. 37 ›› Issue (17): 94-98.doi: 10.11924/j.issn.1000-6850.casb2020-0251

所属专题：畜牧兽医

• 畜牧·动物医学·蚕·蜂 • 上一篇下一篇

雌二醇对哺乳动物子宫内膜血管生成调控的研究进展

孙宛序¹(), 黄启震², 李博宇¹, 苏运泽¹, 张翘楚¹, 肖龙菲¹(), 齐晓龙¹, 邢凯¹, 王相国¹, 盛熙晖¹, 郭勇¹, 倪和民¹()

¹北京农学院动物科学技术学院,北京 102206
²中国动物疫病预防控制中心,北京 100125

收稿日期:2020-07-13 修回日期:2020-09-15 出版日期:2021-06-15 发布日期:2021-06-29
通讯作者: 肖龙菲,倪和民
作者简介:孙宛序,女,1995年出生,河北省晋州人,研究生,研究方向为辅助生殖与繁殖育种。通信地址：102206 北京市昌平区回龙观朱辛庄北农路7号北京农学院动物科学技术学院辅助生殖与繁殖育种实验室,E-mail：717207148@qq.com。
基金资助:
20年创新团队“科技创新服务能力建设”(BAIC004-2020);北京农学院青年科学基金项目“褪黑素对猪精子热应激的保护作用及机制研究”(QNKJ202005)

‘The Regulation by Estradiol on Mammalian Endometrial Angiogenesis: Research Progress

Sun Wanxu¹(), Huang Qizhen², Li Boyu¹, Su Yunze¹, Zhang Qiaochu¹, Xiao Longfei¹(), Qi Xiaolong¹, Xing Kai¹, Wang Xiangguo¹, Sheng Xihui¹, Guo Yong¹, Ni Hemin¹()

¹College of Animal Science and Technology, Beijing University of Agriculture, Beijing 102206
²China Animal Epidemic Disease Prevention and Control Center, Beijing 100125

Received:2020-07-13 Revised:2020-09-15 Online:2021-06-15 Published:2021-06-29
Contact: Xiao Longfei,Ni Hemin

摘要/Abstract

摘要：

随着畜牧养殖业的发展,雌性动物的妊娠问题已经越来越突出。值得关注的是,在畜牧兽医产科临床上,妊娠过程中动物子宫血管的生成不足会导致胚胎着床困难增加、流产和胎儿停止发育等问题。近年来临床及实验室对肿瘤血管生成的作用及生成机制的研究颇多,因肿瘤血管的生长机制与子宫内血管的生长机制存在一定的类似性。所以,借鉴肿瘤血管生成的相关研究,了解血管生成的作用及血管生成的机制,为后期进一步研究雌二醇对反刍动物子宫内膜血管形成的机制奠定基础。

关键词: 血管生成, 雌二醇, 血管内皮生长因子, 子宫血管

Abstract:

With the development of animal husbandry, the pregnancy problem of female animals has become more and more prominent. It is worth noting that in the clinical practice of animal husbandry and veterinary medicine, insufficient formation of blood vessels in the uterus of animals during pregnancy could increase the difficulty in embryo implantation, miscarriage and fetal development. In recent years, there have been many studies on the role and mechanism of tumor angiogenesis in clinics and laboratories. Since there is a similarity between the growth mechanism of tumor blood vessels and the growth mechanism of blood vessels in the uterus, based on the relevant research of tumor angiogenesis, we studied the role of angiogenesis and the mechanism of angiogenesis. The research could lay a foundation for further exploring the mechanism of estradiol on the formation of endometrial blood vessels in ruminants.

Key words: angiogenesis, estradiol, vascular endothelial growth factor, uterine blood vessels

中图分类号:

S857.2+1

孙宛序, 黄启震, 李博宇, 苏运泽, 张翘楚, 肖龙菲, 齐晓龙, 邢凯, 王相国, 盛熙晖, 郭勇, 倪和民. 雌二醇对哺乳动物子宫内膜血管生成调控的研究进展[J]. 中国农学通报, 2021, 37(17): 94-98.

Sun Wanxu, Huang Qizhen, Li Boyu, Su Yunze, Zhang Qiaochu, Xiao Longfei, Qi Xiaolong, Xing Kai, Wang Xiangguo, Sheng Xihui, Guo Yong, Ni Hemin. ‘The Regulation by Estradiol on Mammalian Endometrial Angiogenesis: Research Progress[J]. Chinese Agricultural Science Bulletin, 2021, 37(17): 94-98.

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雌二醇对哺乳动物子宫内膜血管生成调控的研究进展

‘The Regulation by Estradiol on Mammalian Endometrial Angiogenesis: Research Progress

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