Abstract: This test will be weaned 60 of the 28-day-old health and weight similar (7.63μ0.52kg) of goods grew up dual hybrid piglets by weight, sex, were divided into five groups. That is, the control group and four test group, which controls imports of fish meal with the original formula group, 1, 2, 3, 4 were used for the test group’s Shandong Jining-production of bio-engineering activity of yeast protein flour substitute 25%, 50 %, 75% and 100% of the imports of fish meal, of a total test four weeks. Add yeast on different levels of protein powder on weaning performance of piglets. The results showed that: Weaned piglets effect of yeast protein replace imported fish meal after no significant changes in the original add fish meal imports after the piglets weaned from 0 to four weeks, the average intake and average daily gain, feeding effective. The comprehensive test indicators, yeast protein powder to 50~75 percent of imported fish meal replacement, added to the diet of piglets weaned piglets performance marked role in promoting and feed costs decline.