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中国农学通报

中国农学通报 ›› 2015, Vol. 31 ›› Issue (2): 101-106.doi: 10.11924/j.issn.1000-6850.2014-1658

• 水产 渔业 • 上一篇    下一篇

两种给药方式下伊维菌素在虹鳟体内的药物代谢动力学研究

康淑媛1,2,韩 冰1,2,王 荻1,卢彤岩1   

  1. (1中国水产科学研究院黑龙江水产研究所,哈尔滨 150070；2上海海洋大学水产与生命学院,上海 201306）
  • 收稿日期:2014-06-11 修回日期:2014-06-11 接受日期:2014-09-05 出版日期:2015-03-19 发布日期:2015-03-19
  • 通讯作者: 康淑媛
  • 基金资助:

    基金项目：公益性行业（农业）科研专项经费“渔药使用风险评估及其控制技术研究与示范”（201203085）。

Pharmacokinetics of Ivermectin in Oncorhynchus mykiss Following Two Ways of Administration

Kang Shuyuan1, 2, Han Bing1,2, Wang Di1, Lu Tongyan1   

  1. (1Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin 150070;2College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306)
  • Received:2014-06-11 Revised:2014-06-11 Accepted:2014-09-05 Online:2015-03-19 Published:2015-03-19

摘要： 研究旨在通过口灌和腹腔注射两种给药方式，研究伊维菌素在虹鳟体内的药动学特征。采用高效液相色谱-紫外检测法（HPLC-UV）研究了以0.3 mg/kg剂量分别单次口灌和腹腔注射伊维菌素后，药物在虹鳟体内的药代动力学特征。结果表明：口灌给药方式下，伊维菌素在虹鳟血浆、肌肉中的药物浓度和时间关系符合一级吸收二室开放模型，而在肝脏、肾脏中符合一级吸收一室开放模型；腹腔注射给药方式下，伊维菌素在虹鳟血浆、肌肉、肝脏和肾脏中的药时关系均符合一级吸收一室开放模型。口灌给药后，伊维菌素在血浆中主要的药动学参数：AUC为123.709 mg/(L?h)、Ka为3.749 h-1、t1/2ke为 466.569 h、Tmax为0.454 h、Cmax为0.319 mg/L。腹腔注射给药后，伊维菌素在血浆中主要的药动学参数：AUC为52.560 mg/(L?h)、Ka为5.033 h-1、t1/2ke为103.236 h、Tmax为1.317 h、Cmax为0.350 mg/L。说明在两种给药方式下，伊维菌素在虹鳟体内的药动学特征存在明显的差异，伊维菌素在腹腔注射给药方式下吸收和消除速率均较口灌给要快。

关键词: 除草活性, 除草活性

Abstract: This experiment was conducted to study Pharmacokinetics of ivermectin in Oncorhynchus mykiss following a single oral administration or intraperitoneal injection. Pharmacokinetics of ivermectin in Oncorhynchus mykiss was studied following a single oral or intraperitoneal injection at dose of 0.3 mg/kg by high-performance liquid chromatography-ultraviolet detection(HPLC-UV). The results showed that: after oral administration, the concentrations versus time of ivermectin in plasma and muscle were well described by two-department open model with first-order absorption, while those in liver and kidney were well described by one-department open model with first-order absorption; after intraperitoneal injection , the concentrations versus time of ivermectin in plasma, muscle, liver and kidney were well described by one-department open model with first-order absorption. After oral administration, the pharmacokinetic parameters in plasma were as follows: AUC=123.709 mg/(L?h), Ka=3.749 h-1, t1?2ke=466.569 h, Tmax=0.454 h, Cmax=0.319 mg/L; After intraperitoneal injection, the pharmacokinetic parameters in plasma were as follows: AUC=52.560 mg/(L?h), Ka=5.033 h-1, t1?2ke=103.236 h, Tmax=1.317 h, Cmax=0.350 mg/L. It stated that pharmacokinetics of ivermectin in Oncorhynchus mykiss were differences between two different administration routes, and intraperitoneal injection led to more rapid absorption and elimination than oral administration.