Abstract: To find out weed occurrence regularity and control methods in wheat field in Sichuan Province under new tillage methods, the traditional tillage was used as the control, the effects of different tillage methods on weed occurrence regularity and yield were studied in the fixed field and spots for five consecutive years. The results showed that weed species in wheat field were basically the same with different tillage methods. The number of weeds was the highest with no-tillage without mulch, followed by tillage, and no-tillage with straw covering was the least. There were two peaks of weed emergence in wheat field, the big peak appeared 2-3 weeks after wheat sowing and the small peak appeared 6-7 weeks after wheat sowing. Effects of weeds on plant height and tillering were not obvious with different tillage methods. The no-tillage with straw covering and tillage obtained the similar yield of wheat, which was higher than that of no-tillage without mulch. The results indicate that no-tillage with straw covering can both significantly reduce the occurrence and damage of weeds, and increase yield of wheat, so it has a wide application prospect.