H5亚型高致病性禽流感病毒的全球传播与进化

doi:10.11924/j.issn.1000-6850.casb17100006

中国农学通报 ›› 2019, Vol. 35 ›› Issue (2): 104-110.doi: 10.11924/j.issn.1000-6850.casb17100006

所属专题：畜牧兽医

H5亚型高致病性禽流感病毒的全球传播与进化

周森

兴业银行股份有限公司

收稿日期:2017-10-07 修回日期:2018-07-07 接受日期:2018-08-13 出版日期:2019-01-11 发布日期:2019-01-11
通讯作者: 周森
基金资助:
2012 年度国家重点基础研究发展计划“气候变化对人类健康的影响研究”(2012CB955501)。

Global Dissemination and Evolution of H5 Highly Pathogenic Avian Influenza Virus

Received:2017-10-07 Revised:2018-07-07 Accepted:2018-08-13 Online:2019-01-11 Published:2019-01-11

摘要/Abstract

摘要： 旨在研究H5 亚型高致病性禽流感病毒的暴发、传播及进化规律，探索不同宿主、宿主行为、地理环境等因素对疾病传播与进化的影响，以期为该疾病未来预防与控制提供建议和理论支持。研究中利用空间分析技术、系统进化分析技术，研究了全球H5 亚型高致病性禽流感疫情（2004—2015 年）的时空爆发、传播和进化规律。结果表明：H5 亚型高致病性禽流感病毒在2004—2008 年出现集中暴发及大面积扩散后，于2011—2015 年出现第二次大面积暴发，同时伴随多种禽流感亚型。此外，对不同地区病毒的遗传差异进行分析，发现地理隔离会造成病毒在区域内鲜有进化或暴发；而病毒在一个地区持续性存在并感染不同宿主，导致病毒的进化及遗传的多样性。研究认为，地理隔离、宿主行为等因素是造成有些地区如南亚、北美洲，病毒遗传差异较小，而有些地区如东北亚、中国等病毒的遗传差异显著的原因之一。

关键词: 钙肥、苹果产量、苹果品质、叶面肥, 钙肥、苹果产量、苹果品质、叶面肥

Abstract: S[Objective] Since 1996, H5 Highly Pathogenic Avian Influenza Virus (HPAIV) has been transmitted all over the world and continued to rapidly evolve. It became a disaster for the poultry industry and a threat for wild birds and mammals. To control and prevent the disease, it’s important to study understanding its outbreaks, spread and evolution. This study aimed to study the outbreaks, spread and evolution of H5 HPAIV, and figure out how the behavior of hosts and geographic environment influence the outbreaks and evolution of H5 HPAI. It will provide provide suggestions and theoretical support for the prevent and control of avian influenza.[Method] We applied phylogenetic analysis and geospatial techniques to investigate the spatiotemporal pattern of H5 Highly Pathogenic Avian Influenza Virus (from 2004 to 2015) transmission, outbreaks and evolution. [Result] There are twice geographical dispersion of H5 Highly Pathogenic Avian Influenza Virus, one is from 2005 to 2008 with one virus subtype (H5N1), and one is from 2014 to 2015 with many subtypes such as H5N2, H5N1, and H5N8. Besides, the genetic distance in different regions showed that in some regions, such as China, the local persistent viruses and different hosts might lead to the variation of genetic distance; and in some regions, such as South Asia and North America. [Conclusion] The geographic isolation and different hosts might contribute to the insignificant difference of viruses.

周森. H5亚型高致病性禽流感病毒的全球传播与进化[J]. 中国农学通报, 2019, 35(2): 104-110.

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H5亚型高致病性禽流感病毒的全球传播与进化

Global Dissemination and Evolution of H5 Highly Pathogenic Avian Influenza Virus

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