昆虫免疫系统中IMD信号通路的研究进展

doi:10.11924/j.issn.1000-6850.casb18080078

摘要/Abstract

摘要： 昆虫的先天免疫反应是抵御病原体入侵的第一道防线，在防御细菌入侵过程中免疫缺陷（IMD）信号通路起到了至关重要的作用。在过去的二十几年中，识别通路中的成分以及了解该通路的分子机制已经取得了重大进展，包括细菌传感和信号转导过程。同时肠道免疫与IMD通路息息相关，也是现在的研究热点。这些发现不仅有助于了解昆虫的免疫信号，同时也为研究哺乳动物NF-B信号通路提供了新的理解。本文总结了IMD通路的最新研究进展，重点综述了正、负调节因子的作用机制。

关键词: 稻草基质, 稻草基质, 制备处理, 水稻育秧

Abstract: Insect innate immunity is the first defense way that fights off microbial infections, and the immune deficiency (IMD) signaling pathway is the most important way that controls the gene expression of most of the antimicrobial peptides in normal immune regulation of insects. In this article, we review current literatures on the insect IMD pathway, and sum up the positive regulation mechanism of IMD signaling pathway including peptidoglycan- recognition proteins and action way, Imd, dFADD and Dredd signal complex formation and regulation pathway, Relish activation and other positive adjustment factors. We also systematically summarize the action modes of negative regulators, such as negative regulation mechanism of PGRPs, ubiquitin and nuclear negative regulators involved in the negative regulation of Imd signaling pathway. This article provides a reference for further understanding the molecular mechanism of the insect immune response pathway.

杨静,马玉堃,付海燕,刘春光,杨峰山. 昆虫免疫系统中IMD信号通路的研究进展[J]. 中国农学通报, 2019, 35(24): 100-108.

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