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中国农学通报

中国农学通报 ›› 2010, Vol. 26 ›› Issue (10): 365-370.

所属专题： 水产渔业

• 水产 渔业 • 上一篇    下一篇

阿维菌素对雄性鲤鱼血清雌二醇含量的影响

马晓燕1,胡庚东1,杨光2,陈家长1   

  • 收稿日期:2009-10-21 修回日期:2010-01-04 出版日期:2010-05-20 发布日期:2010-05-20
  • 基金资助:

    中央级公益性科研院所基本科研业务费专项资金项目

Effects of Avermectins on the Serum Estradiol Content in Male Cyprinus carpio.

Ma Xiaoyan1, Hu Gengdong1, Yang Guang2, Chen Jiazhang1   

  • Received:2009-10-21 Revised:2010-01-04 Online:2010-05-20 Published:2010-05-20

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摘要：

本实验研究了阿维菌素对雄性鲤鱼（Cyprinus carpio）的急性毒性以及在不同暴露浓度和不同作用时间下低剂量阿维菌素对雄性鲤鱼血清雌二醇含量的影响。结果表明：阿维菌素对鲤鱼的24 h、48 h、72h和96 h LC50分别为134.12μg?L-1、60.55μg?L-1、45.31μg?L-1和33.50μg?L-1，安全浓度为3.35μg?L-1；长期（20 d）暴露时，在低浓度（3.2~5.6μg?L-1）范围内阿维菌素对雄性鲤鱼血清雌二醇的合成产生了抑制作用，当浓度为5.6μg?L-1时，抑制作用最强，与对照组相比血清雌二醇含量降低了28.8%；在高浓度组10.0μg?L-1和18.0μg?L-1，鲤鱼血清雌二醇浓度水平与空白对照组相比均没有显著差异（P>0.05）。在5.6μg?L-1浓度下，各处理组时间的血清雌二醇含量均低于对照组，其中第20天时雌二醇含量最低，与对照组相比浓度降低了28.8%（P<0.01）。在染毒鲤鱼血清雌二醇含量和阿维菌素作用时间或暴露浓度之间不存在明显的时间-效应或剂量-效应关系。血液中雌激素含量的变化直接影响到鱼体的生殖功能及性征变化。由此推测，体内因富集阿维菌素所导致血清中雌二醇浓度变化的鱼体可能出现某种程度的生殖缺陷，以致影响到鱼类种族的繁衍[1]。

关键词: 南通、冬小麦、气象、产量、构成因素, 南通、冬小麦、气象、产量、构成因素

Abstract:

Avermectins is considered one of the most commonly used pesticides in China and probably the world. Studies on avermectins acute toxicity to Cyprinus carpio and effects of low level avermectins on serum estradiol contents in male Cyprinus carpio at different effecting time and exposure concentrations were done. Results of toxicity test showed that 24 h, 48 h ,72 h and 96 h LC50 values were 134.12μg?L-1，60.55μg?L-1 ,45.31μg?L-1and 33.50μg?L-1 respectively. The safety concentration of avermectin to Cyprinus carpio was 3.35μg?L-1, therefore it was virulent toxic to fish. Under effecting time of 20 days, the synthesis of serum estradiol in male C. carpio was inhibited by avermectin at the lower concentrations ranging from 3.2 to 5.6μg?L-1. The most strongest inhibiting effect happened when the avermectin concentration was 5.6μg?L-1, and the content of serum estradiol reduced by 28.8% compared to the control group. However, the synthesis of serum estradiol had no obvious difference at higher concentrations of 10.0μg?L-1and 18.0μg?L-1. The contents of serum estradiol in male C. carpio were lower than the control group at all effecting time at the concentration of 5.6μg?L-1, and on the 20th day the serum estradiol content showed the lowest value by induced 28.8% compared to the control one. And there was no significant time-response or dose-response relationships between serum estradiol contents in male C. carpio and the effecting time or exposure concentrations of averectin. It is suggested that low level avermectins could induce depressions of serum estradiol in fish,thus threatening reproduction of fish.