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中国农学通报 ›› 2014, Vol. 30 ›› Issue (21): 285-288.doi: 10.11924/j.issn.1000-6850.2013-3081

所属专题: 园艺

• 食品 营养 检测 安全 • 上一篇    下一篇

茶黄素提取物及茶黄素片的急性毒性

张建勇 江和源 王岩 刘东英   

  • 收稿日期:2013-11-25 修回日期:2013-12-19 出版日期:2014-07-25 发布日期:2014-07-25
  • 基金资助:
    浙江省茶产业重点科技创新团队“茶叶天然产物绿色高效制备技术研究”(2011R50024);浙江省“三农六方”科技协作计划项目“夏秋茶鲜叶发酵制备高品质速溶红茶的产业化加工技术研究”。

Study on the Acute Toxicity of Theaflavins and Theaflavins Tablet

  • Received:2013-11-25 Revised:2013-12-19 Online:2014-07-25 Published:2014-07-25

摘要: 以茶黄素提取物及终端产品茶黄素片为原料,采用急性毒性试验方法,研究试验小鼠对茶黄素提取物和茶黄素片的急性毒理特性。结果表明,茶黄素提取物对雌性小鼠的急性经口LD50为2710.0 mg/kg体重,是成人日用量的(10~20 mg/kg)的136~271倍;对雄性小鼠LD50为3160.0 mg/kg体重,是成人日用量的(10~20 mg/kg)的158~316倍。茶黄素片对雌性小鼠的急性经口LD50为20000.0 mg/kg体重,是成人日用量的(40~50 mg/kg)的400~500倍;对雄性小鼠的急性经口LD50为14700.0 mg/kg体重,是成人日用量的(40~50 mg/kg)的294~368倍。茶黄素提取物和茶黄素片对雄性小鼠和雌性小鼠的急性经口LD50,均大于成人日用量的100倍,说明茶黄素提取物和茶黄素片的毒性较小,符合保健食品的急性毒性评价标准。

关键词: 秋季连阴雨, 秋季连阴雨, 大尺度环流, 副热带西风急流, 副高, 南亚高压

Abstract: The acute toxicity properties of theaflavins and theaflavins tablet was carried out to evaluate by acute toxicity test method. The results showed that, the female mouse acute oral LD50 of theaflavins extracts was 2710.0mg/kg body weight, which was 136 times to 271 times of adultdaily dose (10mg/kg to 20mg/kg) . The male mice acute oral LD50 of theaflavins extracts was 3160.0mg/kg body weight, which was 158 times to 316 times of adult daily dose (10mg/kg to 20mg/kg). The female mice acute oral LD50 of theaflavins tablet was 20000.0mg/kg body weight, which was 400 times to 500 times of adult daily dose (40mg/kg to 50mg/kg) . The male mice acute oral LD50 of theaflavins tablet was 14700.0mg/kg body weight, which was 294 times to 368 times of adult daily dose (40mg/kg to 50mg/kg) . In a word, the male mice and female mouse acute oral LD50 of theaflavins extracts and theaflavins tablet were more than 100 times of adult dosage. It illustrated that the theaflavin extract and theaflavins tablet have less toxic, and was In accordance with the acute toxicity evaluation standards of health food.