槲皮素药代动力学与生物活性的研究进展

doi:10.11924/j.issn.1000-6850.casb15120084

中国农学通报 ›› 2016, Vol. 32 ›› Issue (13): 177-181.doi: 10.11924/j.issn.1000-6850.casb15120084

槲皮素药代动力学与生物活性的研究进展

许广人,苏建明

湖南省长沙市芙蓉区湖南农业大学2教219室,湖南省长沙市芙蓉区湖南农业大学2教219室

收稿日期:2015-12-14 修回日期:2016-04-13 接受日期:2016-01-22 出版日期:2016-05-17 发布日期:2016-05-17
通讯作者: 苏建明
基金资助:
湖南省研究生科研创新项目“槲皮素对伏马毒素B1 致小鼠肝细胞氧化损伤的干预作用与机制研究”(CX2015B257)；湖南农业大学大学生科技创新基金项目“槲皮素对烟曲霉毒素致小鼠肝细胞损伤的保护作用研究”。

Advances in Pharmacokinetics and Biological Activity of Quercetin

Received:2015-12-14 Revised:2016-04-13 Accepted:2016-01-22 Online:2016-05-17 Published:2016-05-17

摘要/Abstract

摘要： 槲皮素(quercetin, QCT)是一种主要存在于水果、蔬菜、草本植物中的黄酮类化合物，近年来广受关注。本研究就2007—2016 年QCT的文献分布情况进行了初步分析，发现发文量总体呈递增趋势；并对其药代动力学以及抗癌、抗肥胖、抗阿尔茨海默病、抗抑郁和免疫调节等生物活性的研究进展进行了综述，以期为QCT的深入研究和进一步开发利用提供参考。

关键词: 思茅松, 思茅松, 引种, 种源/家系, 苗期测定

Abstract: Quercetin (QCT) is one of the main flavonoids compounds in fruits, vegetables and herbs, and has drawn wide attention in recent years. In this paper, the distribution of literatures concerning quercetin from 2007 to 2016 was analyzed. The results showed that the number of the published literatures on quercetin presented an increasing trend. Then the research advances in pharmacokinetics of quercetin and its biological activities such as anti-cancer, anti-obesity, anti-Alzheimer disease, anti-depression and immunoregulation were reviewed to provide a reference for future research and utilization of quercetin.

许广人,苏建明. 槲皮素药代动力学与生物活性的研究进展[J]. 中国农学通报, 2016, 32(13): 177-181.

参考文献

[1] Manach C, Scalbert A, Morand C, et al. Polyphenols: food sources and bioavailability[J]. Am. J. Clin. Nutr., 2004, 79(5):727-747.
[2] 朱红岗, 凌明. 大鼠体内槲皮素的血药浓度测定及药代动力学研究[J]. 中国药业, 2013, 22(2):14-15.
[3] Wein S, Wolffram S. Oral bioavailability of quercetin in horses[J]. J Equine Vet Sci, 2013, 33 (6) :441-445.
[4] Moon Y J, Wang L, DiCenzo R, et al. Quercetin pharmacokinetics in humans[J]. Biopharm. Drug Dispos, 2008, 29(4):205-217.
[5] 程军, 于治国, 毕开顺. 脑得生丸中中药成分红花的药效成分槲皮素在兔体内的药代动力学研究[J]. 中华临床医药, 2004, 5(1):25-27.
[6] Zhen O Y, Xu C, Yuan W, et al. Pharmacokinetic study of rutin and quercetin in rats after oral administration of total flavones of mulberry leaf extract [J]. Rev Bras Farmacogn, 2013, 23(5): 776-782.
[7] 邓晓慧, 宋海岩, 张东军. 槲皮素对乳腺癌细胞增殖及Survivin表达的影响[J]. 中国医院药学杂志, 2013, 33(12):965-967.
[8] Pan H C, Jiang Q, Yu Y, et al. Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells[J]. Neurochem Int, 2015, 80:60-71.
[9] Sharmila G, Bhat F A, Arunkumar R, et al. Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in?vivo model[J]. Clin Nutr, 2014, 33(4):718-726.
[10] Lee S H, Lee E J, Min K H, et al. Quercetin enhances chemosensitivity to gemcitabine in lung cancer cells by inhibiting heat shock protein 70 expression[J]. Clin Lung Cancer, 2015, 16(6):235-243.
[11] Rockenbach L, Bavaresco L, Farias P F, et al. Alterations in the extracellular catabolism of nucleotides are involved in the antiproliferative effect of quercetin in human bladder cancer T24 cells[J]. Urol Oncol, 2013, 31(7):1204-1211.
[12] Zhang J Y, Lin M T, Zhou M J, et al. Combinational?treatment?of curcumin and?quercetin?against?gastric cancer?MGC-803 cells in vitro[J]. Molecules, 2015, 20(6):11524-11534.
[13] Wang G, Zhang J, Liu L, et al. Quercetin?potentiates doxorubicin mediated antitumor effects against?liver cancer?through p53/Bcl-xl[J]. PLoS One, 2012, 7(12)?:e51764.
[14] Cao C, Sun L, Mo W, et al. Quercetin?mediates β-catenin in pancreatic?cancer?stem-like cells[J]. Pancreas, 2015, 44(8):1334-1339.
[15] Gardi C, Bauerova K, Stringa B, et al. Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis[J]. Arch Biochem Biophys, 2015, 583:150-157.
[16] 刘佳佳, 羊建, 邬于川, 等. 中性粒细胞自发性凋亡及槲皮素对其影响的研究[J]. 医学研究杂志, 2007, 26(4):55-57.
[17] 王兴红, 常陆林, 王丽菲. 槲皮素对糖尿病大鼠肾脏氧化应激和血清炎症相关因子的影响[J]. 中药药理与临床, 2014, 30(4):39-42.
[18] Nabavi S M, Nabavi S F, Eslami S, et al. In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue[J]. Food Chem, 2012, 132:931-935.
[19] Almaghrabi O A. Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney[J]. Saudi J Biol Sci, 2015, 22:227-231.
[20] El-Nekeety A A, Abdel-Azeim S H,?Hassan A M, et al. Quercetin inhibits the cytotoxicity and oxidative stress in liver of rats fed aflatoxin-contaminated diet[J]. Toxic Rep, 2014, 1:319- 329.
[21] Ramyaa P, Krishnaswamy R, Padma V V. Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells-up regulation of Nrf2 expression and down regulation of NF-κB and COX-2[J]. Biochim Biophys Acta, 2014, 1840:681-692.
[22] Sharma D R, Sunkaria A, Wani W Y, et al. Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1α signaling pathway[J]. NeuroToxicology, 2015, 51:116-137.
[23] Hu J, Yu Q W, Zhao F, et al. Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells[J]. Chem-Biol Interact, 2015, 240:38-46.
[24] Seo M J, Lee Y J , Hwang J H, et al. The inhibitory effects of quercetin on obesity and obesity-induced inflammation by regulation of MAPK signaling[J]. J Nutr Biochem, 2015, 26(11):1308-1316.
[25] Nabavi S F, Russo G L, Daglia M, et al. Role of quercetin as an alternative for obesity treatment: You are what you eat![J]. Food Chem, 2015, 179:305-310.
[26] Jin X, Su R, Li R, et al. Amelioration of particulate matter-induced oxidative damage by vitamin c and quercetin in human bronchial epithelial cells[J]. Chemosphere, 2016, 144:459-466.
[27] 李莉, 司松波. 槲皮素对小鼠动情周期及免疫功能的调节作用[J]. 中国免疫学杂志, 2012, 28:1092-1095.
[28] Awad E, Austin D, Lyndon A R. Effect of black cumin seed oil (Nigella sativa) and nettle extract(Quercetin) on enhancement of immunity in rainbow trout, Oncorhynchus mykiss (Walbaum)[J]. Aquaculture, 2013, 388–391:193-197.
[29] Hager-Theodorides A L, Goliomytis M, Delis S, et al. Effects of dietary supplementation with quercetin on broiler immunological characteristics[J]. Anim Feed Sci and Technol, 2014, 198:224-230.
[30] Park H J, Lee C M, Jung I D, et al. Quercetin regulates Th1/Th2 balance in a murine model of asthma[J]. Int Immunopharmacol, 2009, 9(3):261-267.
[31] 王斯慧,黄琬凌, 陈庆松, 等. 芦丁、槲皮素对α-淀粉酶抑制活性研究[J]. 食品与发酵科技, 2012, 48(3):34-37.
[32] Dechandt C R P, Siqueira J T, Souza D L P D, et al. Combretum lanceolatum?flowers extract shows antidiabetic activity through activation of AMPK by quercetin[J]. Rev Bras Farmacogn, 2013, 23(2):291-300.
[33] Sabogal-Guáqueta A M, Mu?oz-Manco J I, Ramírez-Pineda J R, et al. The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice[J]. Neuropharmacology, 2015, 93:134-145.
[34] Islam M R, Zaman A, Jahan I, et al. In silico QSAR analysis of quercetin reveals its potential as therapeutic drug for Alzheimer's disease[J]. J Young Pharm, 2013, 5(4):173-179.
[35] 刘慧芳, 欧阳迎春, 刘应才, 等. 槲皮素对大鼠主动脉环的舒张作用及机[J]. 泸州医学院学报, 2008, 31(3):265-268.
[36] Mokrzycki K. Anti-atherosclerotic efficacy of?quercetin?and sodium phenylbutyrate in rabbits[J]. Ann Acad Med Stetin, 2000, 46:189-200.
[37] Holzmann I, da Silva L M, Corrêa da Silva J A, et al. Antidepressant-like effect of?quercetin?in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways[J]. Pharmacol Biochem Behav, 2015, 136:55-63.
[38] Gomes I B, Porto M L, Santos M C, et al. Renoprotective,?anti-oxidative and?anti-apoptotic effects of oral low-dose?quercetin?in the C57BL/6J model ofdiabetic?nephropathy[J]. Lipids Health Dis, 2014, 13:184.
[39] Lee M, Son M, Ryv E, et al. Quercetin-induced apoptosis prevents EBV infection[J]. Oncotarget, 2015, 6(14):12603-12624.
[40] Li S, Xie W, Cai H, et al. Hydroxyl radical scavenging mechanism of human erythrocytes by quercetin-germanium ( Ⅳ) complex[J]. Eur J Pharm Sci, 2012, 47(1):28-34.
[41] Ghosh N, Chakraborty T, Mallick S, et al. Synthesis, characterization and study of antioxidant activity of quercetin-magnesium complex[J]. Spectrochim Acta Mol Biomol Spectrosc, 2015, 151:807-803.

槲皮素药代动力学与生物活性的研究进展

Advances in Pharmacokinetics and Biological Activity of Quercetin

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