铁调素对动物机体铁代谢及妊娠铁营养的调节作用

doi:10.11924/j.issn.1000-6850.casb20200200140

中国农学通报 ›› 2020, Vol. 36 ›› Issue (23): 118-123.doi: 10.11924/j.issn.1000-6850.casb20200200140

• 畜牧·动物医学·蚕·蜂 • 上一篇下一篇

铁调素对动物机体铁代谢及妊娠铁营养的调节作用

李美荃¹(), 佟荟全¹, 王静¹, 郭荣富²()

¹昆明学院农学与生命科学学院,昆明 650214
²云南农业大学动物科学技术学院,云南省动物营养与饲料重点实验室,昆明 650201

收稿日期:2020-01-04 修回日期:2020-03-22 出版日期:2020-08-15 发布日期:2020-08-13
通讯作者: 郭荣富
作者简介:李美荃,女,1986年出生,黑龙江哈尔滨人,讲师,博士,研究方向为动物营养与饲料科学,通讯地址：650214云南省昆明市官渡区浦新路2号昆明学院,E-mail： limeiquan2010@163.com。
基金资助:
云南省教育厅科学研究基金项目“小分子肝素诱导猪肝细胞Hepcidin下调表达的BMP-SMAD信号通路研究”(2018JS390);云南省科技厅科技计划项目“LWMH对新生仔猪缺铁性贫血的BMP-SMAD及Jak2-STAT3响应机制研究”(2018FH001-042);云南省重大科技专项基金项目“种猪生产营养饲料技术集成与示范”(2012ZA018-3)

Regulation of Hepcidin on Iron Metabolism and Pregnancy Iron Nutrition in Animals

Li Meiquan¹(), Tong Huiquan¹, Wang Jing¹, Guo Rongfu²()

¹College of Agriculture and Life Sciences, Kunming University, Kunming 650214
²Yunnan Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201

Received:2020-01-04 Revised:2020-03-22 Online:2020-08-15 Published:2020-08-13
Contact: Guo Rongfu

摘要/Abstract

摘要：

铁是动物体必需的微量元素,缺铁引发的贫血性疾病在新生动物中所占比例较大,缺铁性贫血是影响新生动物健康及其遗传生长潜力的关键环节。因此,开展改善缺铁性贫血的研究对动物健康具有重要科学意义。铁调素(Hepcidin)调节铁中心代谢、参与体内铁吸收与转运、调控铁营养对母体胎儿生长发育和新生动物铁代谢具有重要生物学意义。随着生物学技术的应用与发展,动物体内越来越多的铁调节蛋白被鉴定,但受限于母体血胎屏障和乳腺屏障,使Hepcidin对于母体-胎盘动物铁代谢的调节机制仍不清楚。本文就铁调素对动物机体铁代谢及妊娠铁营养相关研究进行综述,为后续从事此方面研究的同行提供参考或指出新的研究方向。

关键词: 动物健康, 铁调素, 铁代谢, 铁, 贫血, 缺氧

Abstract:

Iron is an essential trace element in animals. Iron deficiency-induced anemia disease accounts for a large proportion in newborn animals. Iron deficiency anemia is a key link that affects the health of newborn animals and their genetic growth potential. Therefore, research on iron deficiency anemia is of great scientific significance to animal health. Hepcidin regulates iron center metabolism, participates in iron absorption and transport in the body, and regulates iron nutrition, it has important biological significance for maternal and fetal growth and iron metabolism in newborn animals. With the application and development of biological technology, more and more iron regulatory proteins have been identified in animals, but restricted by the maternal blood-fetal barrier and the mammary barrier, hepcidin's regulation mechanism of maternal-placental iron metabolism is still unclear. By reviewing relative researches about the regulation of hepcidin on iron metabolism of animal body and iron nutrition in pregnancy, the paper aims to provide new research directions for colleagues in this field.

Key words: animal health, hepcidin, iron metabolism, iron, anemia, hypoxia

中图分类号:

S856.9

李美荃, 佟荟全, 王静, 郭荣富. 铁调素对动物机体铁代谢及妊娠铁营养的调节作用[J]. 中国农学通报, 2020, 36(23): 118-123.

Li Meiquan, Tong Huiquan, Wang Jing, Guo Rongfu. Regulation of Hepcidin on Iron Metabolism and Pregnancy Iron Nutrition in Animals[J]. Chinese Agricultural Science Bulletin, 2020, 36(23): 118-123.

图/表 2

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铁调素对动物机体铁代谢及妊娠铁营养的调节作用

Regulation of Hepcidin on Iron Metabolism and Pregnancy Iron Nutrition in Animals

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