1 Wolff JA, Malone RW, Williams P, et al. Direct gene transfer into mouse muscle in vivo. Science, 1990,(247):1465~146 2 Tang DC, Devit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature, 1992,(356):152~154 3 Spencer G S G and Williamson E D. Increased growth in lambs following immunization against somatostatin: Preliminary observations. Animal Production, 1981,(2):376~378 4 孙树汉主编.核酸疫苗[M].上海:第二军医大学出版社,2000.1~5 5 徐文忠,陈萍.免疫中和体内生长抑素促进动物生长[J].国外畜牧科技,1992,19(2):17~19 6 胡晓愚,王勤,王锐,等.生长激素释放肽的合成及促生长活性[J].生物化学与生物物理进展,1995,22(6):549~552 7 刘亮,来鲁华,李崇熙.生长激素分泌促进剂及构效关系研究进展[J].生物化学与生物物理进展,1998,25(3):226~231 8 王艳玲,陈伟华,韩正康.不同剂量半胱胺对肉用仔鸡增重及血液生长抑素、生长激素含量的影响[J].中国畜牧杂志,1997,33(4):11~13 9 王彦波,许梓荣.生长抑素抑制剂—半胱胺的研究进展[J].饲料研究,2003,(4):20~22 10 曾义祥,杜念兴.生长抑素基因在大肠杆菌中的表达[J].遗传学报,1991,18(3):282~288 11 刘永庆,潘杰彦,陈溥言,等.生长抑素基因在大肠杆菌pThioHis表达系统中的克隆与表达[J].中国生物制品学杂志,2003,16(1):19~23 12 莫晓群,崔治中,杜念兴.乙肝表面抗原和生长抑素融合基因在杆状病毒中表达[J].农业生物技术学报,1995,3(2):69~7 13 徐文忠,杜念兴,李光地,等. 生长抑素与乙肝表面抗原融合基因重组痘苗病毒的构建及其表达[J].南京农业大学学报,1992,15(3):74~80 14 徐文忠,杜念兴,李光地,等.促进动物生长的新型基因工程疫苗研究[J].中国科学B辑,1993,23(12):1272~1278 15 Donnelly, Feltquate D M , Heaneys R G, et al. DNA vaccines [J]. Immunol, 1997:2278~228 16 Wolff JA and Budker V. The Mechanism of Naked DNA Uptake and Expression [J]. Advances in Genetics,2005,(54):3~20 17 曹少先,张文伟,茆达干,等.生长抑素基因疫苗质粒pcS/2SS的构建、表达及免疫[J].农业生物技术学报,2005,13(4):477~481 18 曹少先,杨利国,张文伟,等.生长抑素基因疫苗质粒pEGS2SS的构建及表达[J].中国兽医学报,2005,9(5):499~502 19 Dubensky TW Jr, Liu MA, Ulmer JB. Delivery Systems for Gene-based Vaccines[J]Molecular Medicine, 2000,6(9):723~732 20 Sylvia DL et al. Recent advances in the use of DNA vaccines for the treatment of diseases of farmed animals. [J]Advanced Drug Delivery Reviews,2000,(43):13~28 21 徐文忠,杜念兴.以痘苗病毒为活载体的基因工程疫苗研究进展[J].中国兽医杂志,1992,(3):44~46 22 M L Michel, M Mancini, E Sobczak, et al. Induction of anti-human immunodeficiency virus (HIV) neutralizing antibodies in rabbits immunized with recombinant HIV-hepatitis B surface antigen particles[J]. Proc Nat Acad Sci USA,1988,(85):7957 23 Chow YH, Chiang BL, Lee YL. Development of Th1 and Th2 populations and the nature of immune response to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes. [J] Immunol, 1998,(160):1320 24 Kim JJ, Bagarazzi ML, Trivedi N, et al . Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes. Nat Biotechnol. 1997, 15(7):641~646 25 Krieg AM, Wu T, Weeratna R,. et al. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs [J] Proc Nat Acad Sci USA,1998,(95):12631~12636 26 Michael JM, Cynthia LB, Robert AG et al. Route an method of delivery of DNA vaccine influence immune responses in mice and non-human primates[J]. Molecular Medicine, 1999,(5):287 27 姜勋平,杨利国.动物基因免疫的原理与方法[J].黑龙江动物繁殖,1999,7(3):22~23 28 曹少先,杨利国,等.生长抑素DNA疫苗pEGS2SS在大鼠体内的表达与分布[J].南京农业大学学报,2005,28(2):137~139 29 吕秋军,丁林茂.生物技术药物临床前安全性评价研究进展[J].中国新药杂志,2001,4(10):252~256 30 Kang KK, Choi SM, Choi JH, et al. Safety evaluation of GX-12, a new HIV therapeutic vaccine: investigation of integration into the host genome and expression in the reproductive organs Intervirology,2003;46(5):270~276 31 Smahel M. DNA vaccines. Cas Lek Cesk, 2002,(22):141 Suppl: 26~32 32 Sedegah M, Hedstrom R, Hobart P, et al. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.[J]Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):66~70 33 娄华.基因免疫研究进展及其面临的问题[J].中国兽医科技,1999,19(12):19~21
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