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中国农学通报

中国农学通报 ›› 2017, Vol. 33 ›› Issue (5): 112-115.doi: 10.11924/j.issn.1000-6850.casb16110122

• 畜牧 动物医学 蚕 蜂 • 上一篇    下一篇

比格犬胫神经皮层体感诱发电位正常值研究

李拓1,丛心宇1,孔学礼1,朱玉欣1,2,张银1,姜代勋1,2,陈武1,2   

  1. (1北京农学院动物科学技术学院,北京102206；2北京农学院兽医学(中医药）北京市重点实验室,北京102206）
  • 收稿日期:2016-11-23 修回日期:2017-01-10 接受日期:2017-01-12 出版日期:2017-03-01 发布日期:2017-03-01
  • 通讯作者: 李拓
  • 基金资助:
    国家自然科学基金“电针改善椎间盘脱出犬脊髓微循环效应的机理研究”(31372473)；北京农学院学位与研究生教育改革与发展项目“脊髓受到不同程度压迫时体感诱发电位变化的研究”(5056516004/024)。

Normal Value of Tibial Nerve Somatosensory Evoked Potentials in Beagle Dogs

Li Tuo1, Cong Xinyu1, Kong Xueli1, Zhu Yuxin1,2, Zhang Yin1, Jiang Daixun1,2, Chen Wu1,2   

  1. (1College of Animal Science and Technology, Beijing University of Agriculture, Beijing 102206;2Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing 102206)
  • Received:2016-11-23 Revised:2017-01-10 Accepted:2017-01-12 Online:2017-03-01 Published:2017-03-01

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摘要： 为了测定比格犬胫神经皮层体感诱发电位(somatosensory evoked potential, SEP)的波形及其潜伏期和波幅的正常值。选用15只健康比格犬，在异氟烷吸入麻醉状态下，使用肌电诱发电位仪电刺激其胫神经，将自制参考电极和记录电极分别放置于头部Fz处和Cz处记录SEP波形。结果表明：15只比格犬刺激左右侧胫神经均可记录到清晰的双向SEP波。刺激左侧胫神经引发的波形潜伏期为P(21.71±1.978) ms、N(32.61±2.568) ms、P-N(10.90±1.338) ms，其变异系数分别为9.11%、7.87%、12.88%；波幅为(2.762±1.230) μV，变异系数为41.47%；刺激右侧胫神经引发的波形潜伏期为P(21.49±1.985) ms、N(32.55±2.359)ms、P-N(11.06±1.153) ms，其变异系数分别为9.24%、7.25%、10.24%；波幅为(2.634±1.092) μV，变异系数为44.55%。潜伏期和波幅左右侧差异均不显著(P>0.05)。对正常比格犬胫神经皮层SEP的测定，获得了清晰的SEP波形及各波潜伏期和波幅的正常值，印证了潜伏期的稳定性优于波幅的稳定性，可以为实验室研究犬病理状态下的SEP和宠物临床应用SEP诊断疾病提供参考依据。

关键词: 复合饮料, 复合饮料, 配方研制, 蒲公英, 夏枯草, 野菊花

Abstract: The aims of the experiment are to determine the tibial nerve somatosensory evoked potential (SEP) waveforms in beagle dogsand measure the normal values of the latency period and amplitude. Fifteen healthy Beagle dogs were tested under isoflurane inhalation anesthesia. The tibial nerve was stimulated by electricity with electromyography evoked potentiometer. The self-made reference electrode and the recording electrode were respectively placed at the head Fz point and Cz pointto record SEP waveform. The results showed that fifteen Beagle dogs could record clear bidirectional SEP waveforms by stimulating the left and right tibial nerves. The latency period of the waveforms triggered by stimulation of the left tibial nerve was P (21.71±1.978) ms, N (32.61±2.568) ms, P-N (10.90±1.338) ms, and the coefficient of variation respectively was 9.11%, 7.87%, 12.88%. The amplitude was (2.762±1.230) μV and its coefficient of variation was 41.47%. The latency of the waveforms triggered by stimulation of the right tibial nerve were P (21.49±1.985) ms, N (32.55±2.359) ms, P-N (11.06±1.153) ms, and the coefficient of variation respectively was9.24%, 7.25%, 10.24%. The amplitude was (2.634±1.092) μV and its coefficient of variation was 44.55%.There was no significant difference in latency period and amplitude between right and left side (P>0.05). The SEP waveforms, normal values of the latency period and amplitude of each wave were obtained by measuring the tibial nerve SEPs in normal Beagle dogs. This confirms that the stability of the latency period is superior to the stability of the amplitude. These results can provide a reference for the study of SEP in dogs under pathological conditions, and alsofor the clinical application of SEP in the diagnosis of diseases.