关键词: 富集系数, 富集系数

Abstract: The preventive and therapeutic effects of three traditional Chinese medicine preparations, i.e. Wenqing (WQ), Xiangdan (XD) and Zhuling (ZL) injections, on endotoxin (ET)-induced acute renal failure (ARF) were investigated in Harbin white rabbit. Forty rabbits were randomly divided into five groups, namely negative control, model, WQ, XD and ZL, eight for each group. The rabbits, except those of negative control group, were given an intravenous injection of E. coli O111B4 ET solution. After the injection of ET, the rabbits of WQ, XD and ZL groups were immediately injected corresponding preparations. The negative control rabbits were given an intravenous injection of normal saline (NS). Liquid injected in every group was balanced in volume. An hour after the injection of ET solution or NS, serial urine samples were collected by a bladder fistula at one time per hour for six hours. After the collection of the urine samples, bleeding was immediately made from heart. To ascertain the preventive effect, the renal functional parameters were measured dynamically in the rabbits of each group. The results indicated that model rabbits developed ARF. However, in the rabbits treated with WQ, urinary output, the excretion of creatinine, urea nitrogen and sodium were significantly increased (P<0.05，P<0.01), renal failure index and the fractional excretion of sodium were markedly decreased (P<0.05，P<0.01)， endogenic creatinine clearance was significantly increased (P<0.05，P<0.01).The changes of the renal functional parameters of XD group animals, except renal failure index and the fractional excretion of sodium, were similar to those of WQ group. It could be concluded that WQ had obvious preventive and therapeutic effect on ARF induced by ET; XD had also good preventive and therapeutic effect on ET-induced ARF; but ZL group rabbits were not halted completely on ET-induced ARF.