L-岩藻糖对母乳寡糖(HMOs)合成的意义及其产业化研究进展

doi:10.11924/j.issn.1000-6850.casb18030039

摘要/Abstract

摘要： 近年来，母乳寡糖的体外合成研究发展迅速，但其产业化进程相对滞后。为了探究其原因，笔者综述了数十年来国内外关于母乳寡糖合成的相关研究成果。结果表明，全细胞发酵合成法是当今公认最具有工业化潜力的母乳寡糖生产方法，同时发现，L-岩藻糖的价格很大程度上限制了母乳寡糖的产业化发展。如今L-岩藻糖的生产仍以天然产物提取为主，存在着原料单一、提取成本高等问题。今后应开发更多的L-岩藻糖生产方法，如利用生物技术手段构建高产L-岩藻糖菌株，同时从农业废弃物资源中提取L-岩藻糖亦具有较好的应用前景。

关键词: 紫花苜蓿, 紫花苜蓿, 苜蓿中华根瘤菌, 结瘤数, 产量

Abstract: In recent years, the synthesis of human milk oligosaccharides (HMOs) in vitro has developed rapidly, but its industrialization process has lagged behind. In order to explore its causes, this paper introduced lots of research results on the synthesis of HMOs at home and abroad in the decades. The results showed that: the whole cell fermentation synthesis method was currently recognized as the most industrialized potential of the production of breast milk oligosaccharides, at the same time, the price of L-fucose limited the industrial development of HMOs largely. Nowadays, the source of L-fucose still mainly was extracted from natural products and there were some problems such as single raw materials and high extraction costs. In future, other more ways for producing L-fucose should be developed, such as constructing a high-yield L-fucose strain by means of biotechnology, and extracting L-fucose from agricultural waste resources also has a good application prospect.

中图分类号:

TS241

王永胜,王硕,张慧林,李冲伟. L-岩藻糖对母乳寡糖(HMOs)合成的意义及其产业化研究进展[J]. 中国农学通报, 2019, 35(11): 127-132.

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