Food preservative has been the one hot spot of food sciences. As the most widely used high-efficient, innoxious natural food preservative, nisin has been widely applied in the preservation of meat，milk，cheese，vegetable etc, and its application area is being steadily extended recently. The latest advances of nisin’s application on active packaging materials, agriculture feed, contraceptive medicine, implantable medical devices are summarized, and the sterilization characteristics and mechanisms of nisin combined with non-thermal inactivation techniques are also introduced in this paper. Moreover, the prospects of nisin’s application are envisioned.
