奶牛围产前期钙的稳态和负DCAD日粮的应用

doi:10.11924/j.issn.1000-6850.casb2021-0870

摘要/Abstract

摘要：

围产期是奶牛泌乳周期乃至一生中最为关键的阶段,围产期的饲养管理对奶牛整个泌乳期的产奶性能、繁殖性能和健康状况都有影响。鉴于围产期奶牛的营养和生理研究的不断深入,尤其是奶牛围产前期钙的稳态得到越来越多的关注,负日粮阴阳离子差(dietary cation-anion difference, DCAD)日粮,即阴离子日粮作为一种有益的探索在国外牛场获得大规模推广应用,本文在综合阐述钙的稳态、吸收、释放规律和负DCAD日粮的特征的基础上,对负DCAD日粮的应用提出生产上的建议：在合理的干物质采食量(dry matter intake, DMI)基础上,目前普遍使用负DCAD日粮和高钙水平相结合,设定-100~ -150 meq/kg的DCAD水平,配合0.4%左右的高镁含量和低磷水平,对应尿液应该在pH 5.5~6.5。

关键词: 围产期, 奶牛, 钙, 负DCAD日粮, 低血钙症, 生产应用

Abstract:

Periparturition is the most critical period of lactation cycle and even the whole life of cows. The feeding management of periparturition has impacts on milking performance, reproductive performance and health status of cows in the whole lactation period. In view of the research about the nutrition and physiology of periparturition cows in recent years, especially that calcium homeostasis of cows during close-up period has been attached with more and more attention, negative DCAD (dietary cation-anion difference) diet or anionic diet has been widely promoted and applied in foreign farms as a beneficial exploration. Based on the comprehensive description of calcium homeostasis, absorption and release rules and the characteristics of negative DCAD diets, this article puts forward production recommendations for the application of negative DCAD diets. On the basis of reasonable DMI (dry matter intake), a combination of negative DCAD diets and high calcium levels is commonly used currently. Set the DCAD level of -100 to -150 meq/kg, combined with the high magnesium content of about 0.4% and low phosphorus level, the corresponding urine pH should be 5.5 to 6.5.

Key words: periparturition, cows, calcium, negative DCAD diet, hypocalcemia, production application

中图分类号:

S823

李岩, 付瑶, 陈勇, 魏政. 奶牛围产前期钙的稳态和负DCAD日粮的应用[J]. 中国农学通报, 2021, 37(35): 88-92.

Li Yan, Fu Yao, Chen Yong, Wei Zheng. Calcium Homeostasis and Application of Negative DCAD Diet in Cows During Close-up Period[J]. Chinese Agricultural Science Bulletin, 2021, 37(35): 88-92.

图/表 5

图1. 奶牛围产期间营养和代谢之间的关系

图2. 日粮中钙的吸收机制

图3. 负DCAD和动物体内钙稳态的联系

图4. 钙在小肠中的吸收

图5. RANK信号调节

参考文献 33

[1]	郭光礼. 经产奶牛围产前期DCAB日粮饲喂与产后瘫痪浅析[J]. 山东畜牧兽医, 2015, 36(2):26-27.
[2]	李启照, 孙维浩, 卫强. 围产前期奶牛日粮中添加过瘤胃脂肪对其干物质采食量和泌乳性能的影响[J]. 中国饲料, 2019(6):55-59.
[3]	彭传文, 祁敏丽, 董永, 等. 围产前期饲喂阴离子盐日粮对奶牛产后代谢疾病发病率的影响[J]. 中国乳业, 2020(10):34-36.
[4]	Chamberlin W G, Middleton J R, Spain J N, et al. Subclinical hypocalcemia, plasma biochemical parameters, lipid metabolism, postpartum disease, and fertility in postparturient dairy cows[J]. Journal of Dairy Science, 2013, 96(11):7001-7013. doi: S0022-0302(13)00647-4 pmid: 24054301
[5]	陈子宁, 李妍, 高艳霞, 等. 围产前期日粮能量水平对荷斯坦奶牛产后生产性能和血液指标的影响[J]. 畜牧兽医学报, 2015, 46(11):2002-2009.
[6]	穆淑琴, 李鹏. 奶牛围产期低血钙症的发生及营养调控措施[J]. 中国牛业科学, 2011, 37(4):41-43.
[7]	Risco C A, Reynolds J P, Hird D. Uterine prolapse and hypocalcemia in dairy cows[J]. Journal of the American Veterinary Medical Association, 1984, 185(12):1517-1519.
[8]	Shock D A, Roche S M, Genore R, et al. A pilot study to evaluate the effect of a novel calcium and vitamin D-containing oral bolus on serum calcium levels in Holstein dairy cows following parturition[J]. Veterinary Medicine: Research and Reports, 2019, 10:151. doi: 10.2147/VMRR URL
[9]	Martinez N, Risco C A, Lima F S, et al. Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease[J]. Journal of Dairy Science, 2012, 95(12):7158-7172. doi: 10.3168/jds.2012-5812 pmid: 23021755
[10]	Venjakob P L, Borchardt S, Heuwieser W. Hypocalcemia—Cow-level prevalence and preventive strategies in German dairy herds[J]. Journal of Dairy Science, 2017, 100(11):9258-9266. doi: S0022-0302(17)30797-X pmid: 28865859
[11]	Venjakob P L, Pieper L, Heuwieser W, et al. Association of postpartum hypocalcemia with early-lactation milk yield, reproductive performance, and culling in dairy cows[J]. Journal of Dairy Science, 2018, 101(10):9396-9405. doi: S0022-0302(18)30662-3 pmid: 30031579
[12]	Horst R L, Goff J P, Reinhardt T A. Role of vitamin D in calcium homeostasis and its use in prevention of bovine periparturient paresis[J]. Acta Veterinaria Scandinavica Supplementum, 2003, 97(97):35.
[13]	Horst R L, Littledike E T. Comparison of plasma concentrations of vitamin D and its metabolites in young and aged domestic animals[J]. Comparative biochemistry and physiology. B, Comparative biochemistry, 1982, 73(3):485-489.
[14]	Goff J P, Horst R L. Role of acid-base physiology on the pathogenesis of parturient hypocalcaemia (milk fever)--the DCAD theory in principal and practice[J]. Acta Veterinaria Scandinavica Supplementum, 2003, 97(97):51.
[15]	Rodriguez M, Salmeron M D, Martin-Malo A, et al. A New Data Analysis System to Quantify Associations between Biochemical Parameters of Chronic Kidney Disease-Mineral Bone Disease[J]. Plos One, 2016, 11(1):e0146801. doi: 10.1371/journal.pone.0146801 URL
[16]	Nelson C D. Vitamin D Metabolism in Dairy Cattle and Implications for Dietary Requirements [C]//Florida Ruminant Nutition Symposium, 2014.
[17]	Pike J W, Lee S M, Benkusky N A, et al. Genomic Mechanisms Governing Mineral Homeostasis and the Regulation and Maintenance of Vitamin D Metabolism[J]. JBMR plus, 2021, 5(1):e10433.
[18]	Goff J P, Koszewski N J. Comparison of 0.46% calcium diets with and without added anions with a 0.7% calcium anionic diet as a means to reduce periparturient hypocalcemia[J]. Journal of Dairy Science, 2018, 101(6):5033-5045. doi: 10.3168/jds.2017-13832 URL
[19]	Kim M H, Kim S H, Park H W, et al. Effects of calcium and genistein on body fat and lipid metabolism in high fat-induced obese mice[J]. Journal of Nutrition and Health, 2006, 39(8):733-741.
[20]	Park J H, Jeong J S, Lee S I, et al. Influence of Dietary Particle Size and Sources of Calcium and Vitamin D3 on Production Performance, Egg Quality and Blood Calcium Concentration of ISA Brown Laying Hens[J]. Animal Nutrition and Feed Technology, 2017, 17(1):1-12. doi: 10.5958/0974-181X.2017.00001.4 URL
[21]	Brömme H J, Dargel R. Effect of in vivo and in vitro application of glucagon, insulin and epinephrine on Ca++-transport properties of liver mitochondria[J]. Acta biologica et medica Germanica, 1979, 38(10):1365-1377. pmid: 162024
[22]	Lean I J, Ondarza M, Sniffen C J, et al. Meta-analysis to predict the effects of metabolizable amino acids on dairy cattle performance[J]. Journal of Dairy Science, 2018, 101(1):340-364. doi: S0022-0302(17)30993-1 pmid: 29128215
[23]	Lean I J, Santos J, Block E, et al. Effects of prepartum dietary cation-anion difference intake on production and health of dairy cows: A meta-analysis[J]. Journal of Dairy Science, 2019, 102(3):2103-2133. doi: S0022-0302(18)31114-7 pmid: 30594362
[24]	Martinez N, Rodney R M, Block E, et al. Effects of prepartum dietary cation-anion difference and source of vitamin D in dairy cows: Health and reproductive responses[J]. Journal of Dairy Science, 2017, 101(3):2563-2578. doi: 10.3168/jds.2017-13740 URL
[25]	Lean I J, Degaris P J, Celi P, et al. Influencing the future: interactions of skeleton, energy, protein and calcium during late gestation and early lactation[J]. Animal Production Science, 2014, 54(9):1177-1189. doi: 10.1071/AN14479 URL
[26]	Mcart J A A, Oetzel G R. A stochastic estimate of the economic impact of oral calcium supplementation in postparturient dairy cows[J]. Journal of Dairy Science, 2015, 98(10):7408-7418. doi: 10.3168/jds.2015-9479 URL
[27]	Lean I J, Degaris P J, Mcneil D M, et al. Hypocalcemia in Dairy Cows: Meta-analysis and Dietary Cation Anion Difference Theory Revisited[J]. Journal of Dairy Science, 2006, 89(2):669-684. pmid: 16428636
[28]	甄玉国, 赵巍, 王兰惠, 等. 围产前期不同钙水平日粮对奶牛血钙水平及钙代谢的影响[J]. 饲料工业, 2016, 37(10):37-42.
[29]	Santos J E P, Lean I J, Golder H, et al. Meta-analysis of the effects of prepartum dietary cation-anion difference on performance and health of dairy cows[J]. Journal of dairy science, 2019, 102(3):2134-2154. doi: S0022-0302(19)30003-7 pmid: 30612801
[30]	Charbonneau E, Chouinard P Y, Tremblay G F, et al. Hay to reduce dietary cation-anion difference for dry dairy cows[J]. Journal of dairy science, 2008, 91(4):1585-1596. doi: 10.3168/jds.2007-0775 pmid: 18349251
[31]	Constable P D, Megahed A A, Hiew M W H. Measurement of urine pH and net acid excretion and their association with urine calcium excretion in periparturient dairy cows[J]. Journal of dairy science, 2019, 102(12):11370-11383. doi: S0022-0302(19)30830-6 pmid: 31548071
[32]	Blanc C D, Van der List M, Aly S S, et al. Blood calcium dynamics after prophylactic treatment of subclinical hypocalcemia with oral or intravenous calcium[J]. Journal of dairy science, 2014, 97(11):6901-6906. doi: 10.3168/jds.2014-7927 pmid: 25200776
[33]	Kerwin A L, Ryan C M, Leno B M, et al. Effects of feeding synthetic zeolite A during the prepartum period on serum mineral concentration, oxidant status, and performance of multiparous Holstein cows[J]. Journal of dairy science, 2019, 102(6):5191-5207. doi: S0022-0302(19)30367-4 pmid: 31005325