欢迎访问《中国农学通报》，
中国农学通报

中国农学通报 ›› 2014, Vol. 30 ›› Issue (35): 93-96.doi: 10.11924/j.issn.1000-6850.2014-0960

所属专题： 畜牧兽医

• 畜牧 动物医学 蚕 蜂 • 上一篇    下一篇

玉屏风复合多糖对免疫抑制小鼠的免疫调节作用

杨鸿   

  1. 佛山科学技术学院
  • 收稿日期:2014-04-04 修回日期:2014-04-04 接受日期:2014-06-17 出版日期:2015-03-18 发布日期:2015-03-18
  • 通讯作者: 邓桦
  • 基金资助:
    广东省自然科学基金“玉屏风多糖抗NDV细胞毒性机制的血清药理学研究”(S2013010012191)；广东省科技计划项目“玉屏风复合多糖临床前研究及新兽药制剂的开发”(2009B020307004)。

Immunoregulatory Effects of YPF-P in Immunosuppressive Mice

  • Received:2014-04-04 Revised:2014-04-04 Accepted:2014-06-17 Online:2015-03-18 Published:2015-03-18

摘要： 为探讨玉屏风复合多糖对免疫功能损伤的调节和保护作用，以环磷酰胺80 mg/kg诱导的免疫低下小鼠为实验动物模型，通过检测小鼠的脾脏指数、脾淋巴细胞增殖能力、血清溶血素和血清中IL-2等指标，观察不同剂量玉屏风复合多糖(100，200，400 mg/kg)对小鼠脾脏指数、脾淋巴细胞增殖能力、血清溶血素和血清IL-2的影响。结果发现，玉屏风多糖能使免疫抑制小鼠的脾脏指数升高，促进脾淋巴细胞的增值；玉屏风多糖可促进正常小鼠血清溶血素抗体的生成，对抗环磷酰胺所致的小鼠血清溶血素抗体分泌减少；玉屏风复合多糖能提高正常小鼠和免疫抑制的小鼠血清的IL-2水平，尤其以中、低剂量组效果较好。结果证实，玉屏风多糖能对抗环磷酰胺诱导的小鼠免疫抑制，提高免疫功能，对小鼠的脾脏功能也有保护作用。

关键词: 再生体系, 再生体系

Abstract: To investigate the immune regulative and protective effect of Yupingfeng polysaccharides (YPF-P) on immunosuppressive mice, the immunosuppressive mouse model was induced by cyclophosphamide (80 mg/kg), and the changes of spleen index, spleen lymphocyte proliferation, serum hemolysin and serum IL-2 were observed in the study. The results showed that YPF- P could improve the spleen index of immunosuppressive mice, to promote the spleen lymphocyte proliferation. YPF- P can promote hemolysin antibody in the serum of normal mice, against serum hemolysin antibody reduction of mice caused by cyclophosphamide reduced, YPF-P could improve the normal mice and immunosuppressive mice serum levels of IL- 2, especially in middle and low dose group. Those results confirmed that YPF- P could resist the immunosuppression of mice induced by cyclophosphamide, and improve immune function and protect the function of spleen.