欢迎访问《中国农学通报》，
中国农学通报

中国农学通报 ›› 2011, Vol. 27 ›› Issue (29): 46-49.

所属专题： 生物技术

• 畜牧 动物医学 蚕 蜂 • 上一篇    下一篇

部分地区传染性胃肠炎病毒株S基因的序列分析

满朝来 于晓龙   

  • 收稿日期:2011-04-25 修回日期:2011-05-03 出版日期:2011-11-15 发布日期:2011-11-15
  • 基金资助:

    猪传染性胃肠炎病毒蛋白对miRNAs抑制作用与其致病性的研究

Sequence Analysis of S Gene of Transmissible Gastroenteritis Virus Isolated from Different Regions

  • Received:2011-04-25 Revised:2011-05-03 Online:2011-11-15 Published:2011-11-15

PDF (PC)

965

摘要：

猪传染性胃肠炎(Porcine Transmissible Gastraenteritis, TGE)是猪的一种高度接触性肠道疾病。本研究以不同地区猪传染性胃肠炎病毒株的S基因为靶序列，序列分析不同地区TGEV病毒株S基因的同源性和进化性关系，序列分析包括遗传距离测定、进化树分析和碱基替换分析等。结果表明：S基因在TGEV不同毒株间高度保守，但S基因存在腺嘌呤碱基（A）向胸腺嘧啶（T）突变的倾向。本研究通过对TGEV S基因核苷酸序列分析可为深入研究TGEV的毒力变化和流行病学提供参考。

关键词: 贵州扁形茶, 贵州扁形茶, 温度控制, 感官品质

Abstract:

Transmissible gastroenteritis (TGE) is an acute highly contagious disease of pigs caused by transmissible gastroenteritis virus (TGEV). In this study, S gene sequences of several TGEV strains derived from different regions were analyzed for the homology and evolution. Sequence analysis of the S gene, including genetic distance measurement, phylogenetic tree analysis, and residue substitution analysis, showed that the S gene was highly conservative between each TGEV strains, but there existed the tendency of adenine nucleotide (A) mutation to thymidine nucleotide (T). This study shows that the nucleotide sequence analysis can form a base or further study on the virulence and epidemiological study of TGEV infections.