组蛋白甲基化和去甲基化研究进展

摘要/Abstract

摘要： 在真核基因中，组蛋白会发生多种共价修饰，其中组蛋白的甲基化在表观遗传学中起重要作用。不同的甲基化位点产生不同的作用机理，组蛋白H3K9的甲基化与异染色质形成、基因沉默有关；组蛋白H3K4的甲基化与基因转录激活有关；组蛋白H3K36的甲基化与RNAPⅡ有一定的关系。最近首次报道了组蛋白甲基化的可逆性，并发现组蛋白去甲基酶：LSD1和含有Jmjc域的组蛋白去甲基酶。这些去甲基酶可使不同程度甲基化的组蛋白H3K4、K9、K36去甲基化，同时与基因转录存在联系。

关键词: 叶绿素, 叶绿素, 萃取, 有机溶剂, 玉米

Abstract: In eukaryotic genes,histones are subject to covalent modifications and histone lysine methylation plays an importance in epigenetics; the different methylation sites have different mechanisms. Histone H3K9 methylation is involved in heterochromatin formation,gene silencing; H3K4 methylation contributes to transcriptional activation and K36 methylation is linked to RNAPⅡ.The first report shows histone methylation is reversible and discovered lysine-specific histone demethylases:LSD1 and Jmjc-domain-containing histone demethylases. They can demethylate different levels of histone H3K4, H3K9and H3K36 methylation, are associated with gene transcription.

中图分类号:

刘飞,靳飞,翟晓巧,,贾峰. 组蛋白甲基化和去甲基化研究进展[J]. 中国农学通报, 2007, 23(2): 56-056.

Liu Fei, Jin Fei, Zhai Xiaoqiao,, Jia Feng. Development of Histone Methylation and Demethylation[J]. Chinese Agricultural Science Bulletin, 2007, 23(2): 56-056.

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