Abstract: Fusarium head blight (FHB) is a worldwide destructive disease of wheat in the warm, semi-humid or humid regions, especially serious in China. The disease not only causes significant losses in yield and reduces grain quanlity, but also induces toxin to contaminated seeds, which is harmful to the healthy of human and livestocks, So it is important to control it. There are several methods to control Fusarium head blight (FHB). Such as using Crop rotation, Soil cultivation and Fertiliser, biological control, Fungicides control, transgenes, resistance to control Fusarium head blight (FHB). All of these methods gain some effect, but also exist their deficiency. Sometimes crop rotation had no significant effect on DON contamination of wheat grain, subsequent reductions in DON contamination were inconsistent when using Soil cultivation and Fertiliser, Unfortunately, under field conditions, the biological control achieved has been shown to be variable and in some tests has failed to give any control, The use of fungicides, however, have not been consistently effective in controlling FHB and in reducing DON formation, transgene-silencing at different generations is a problem to use transgenes, Information on location of QTL for FHB resistance should improve dramatically in the near future on resistance to control Fusarium head blight (FHB). Therefore, it is pressing to improve control methods, especially to DON.