Abstract:

Anemonin is the main component of pulsatilla; it has significantly control efficiency on diarrhea. The aim of this study was to clarify the control efficiency mechanism of Anemonin on diarrhea .The diarrhea model was created by PRV and E.coli. The effects of Anemonin on intestinal micro-structure of diarrheal mice were dynamic obserated by microscopy. The results showed that the intestinal villus of the infected mice were acutely injuried. The intestinal villus displaied atrophy and dehydration; the villus tips appeared vacuolization and swelling, but the bases constricted. The injuries of prevention and treatment groups were lighter than the self-healing group, and the recovery time of intestinal mucosal was significantly shorter. The results suggested that the Anemonin can significantly preventive mice diarrhea infected by PRV and E.coli, the mechanism of the Anemonin for control diarrhea maybe has some relationships with lessen injuries and accelerate restored of intestinal mucosal.