Abstract: To provide a scientific basis for the integrated control of (Pseudomonas syringae pv. tabaci ) by finding out the causation and occurrence regularity of the disease in Dandong, Liaoning, we did a field experiment with the isolated infection and stage exposure method in 2013- 2015, to study the occurrence regularity and optimal control time of the tobacco angular leaf spot disease combined with annual climate factors. The results showed that: the peak period of angular leaf spot was from mid June to late August; there were at least two infection peaks in July to mid August each year, and the infection difference between the peak years was closely related to annual climate factors; based on the conditions of continuous rain for more than 3 days or humidity more than 80%, then the sustained high temperature above 28℃ for 2-4 days could easily led to the infection peak of field angular leaf spot. The disease control focused on prevention, people should predict the prevalence trend of the disease and prepare for disease prevention in advance based on the epidemic of the disease and climate change, especially sunny weather after stormy weather, rainy days, heavy precipitation and high humidity, which should be taken as a key prevention and control period.