The major chemical components of flue-cured tobacco leaves were analyzed in North of Hunan. The results indicated that content of total nitrogen, alkaloid , water-soluble sugar and reducing sugar were higher in G80 and Hongda, but Potassium was lower than others; Each index contents of V2,Yuyan87, Yuyan317 was in the middle; The content of total nitrogen, alkaloid, water-soluble sugar and reducing sugar were lower in RG11,and Potassium was higher.