Abstract:

As a representative of polycyclic aromatic hydrocarbons, Benzopyrene was widespread in the natural environment. It could be metabolized by cytochrome P450 monooxygenase such as CYP1A1.The ultimate metabolite BaP-7,8-dihydrodiol-9,10-epoxide thought to be critical for its immunotoxic activity. Fish immune system was in the special stage of evolution. This paper overviewed the toxicity mechanisms and channels of benzopyrene on fish immune system from mainly immune factors. And the main immunostimulants used in aquaculture to deal with the immune toxicity caused by organic pollutants and other environmental factors were also briefly discussed.