Abstract: The new smoky disinfectant Canxun’an (CXA) had been researched and made up with the high-Chloric agent. In order to make sure its disinfect effect and safety for silkworm, the experiment of silkworm pathogen disinfected by CXA with two ways, the toxicity and safety test were carried out. The result showed that a certain dosage of CXA burned and airproofed a certain period of time can make most of the pathogen of silkworm usually meeting inactivate completely; and it have no side-effect to silkworm to disinfect with smoking of CXA.