Abstract: This article researched to the main economic characters’superiority under high density planting of regional test strains and certificated varieties of the hybrid cotton in south Xinjiang of China, so as to provide theoretical basis for using hybrid utilization. This article used to the data of lint yield and fiber traits in regional test strains and certificated varieties of the hybrid cotton in south Xinjiang from 2005 to 2012, and analyzed them. Hybrid cotton proceed to start-fast develop-rapidly decline process at the high density of drip irrigation in regional test, the amplitude index of the number of bolls, boll weight and lint percent for hybrid cotton of regional test strains were higher than the conventional cotton. For the average lint yield, G. hirsutum×G. hirsutum cotton combination was a little higher than the conventional cotton, but the superiority was not remarkable. Fiber length and fiber strength was little lower than the conventional cotton, but the effect was not remarkable. The G. hirsutum×G. hirsutum cotton of certified varieties for the number of bolls per plant and boll weight were remarkable higher than the conventional upland cotton except the lint percent. But for the number of bolls per hectare, which was lower than convention cotton as much as 30000. The G.hirsutum×G.barbadense cotton was more excellent than G. hirsutum×G. hirsutum hybrid and conventional upland cotton for the number of bolls per plant, fiber quality, disease resistance and so on, but it was lower than the conventional upland cotton for the bolls weight, lint percent, average lint yield, it was below 27.0%, 11.3%, 7.0%, respectively. The hybrid cotton of the main economic characters’superiority were not obvious higher than conventional upland cotton, so it was necessary to study on strong heterosis of hybrid cotton breeding and planting patterns at the high-density in South Xinjiang.