Abstract: The stereoscopic planting is an important measures and effective way to use of land rational, make full use of solar energy, improve the yield and quality, prolong the using life of perennial forage grass. In order to analyze forage combinations, fertilization, irrigation quota, the influence on the yield of the significant degree, the optimal combination of different levels of multiple factors and law of water consumption and water consumption of mixed pasture in arid desert area, this paper made mixed sowing and seeding irrigation experiment under different water and fertilizer conditions of perennial grasses, and the results were analyzed using SPSS software. The results showed that, the optimal combination of mixed sowing and seeding was combination of Alfalfa and Elymus sibiricus, fertilization 18471 kg/hm², irrigation quota was 3600 m³/hm², the main factors affecting of yield was irrigation quota, the maximum water consumption intensity of mixed pasture was 86 m³/(hm²·d) during growth period, and irrigation quota was 3600 m³/hm² of mixed pasture. Through comprehensive analysis, this paper evaluates the superiority of mixed pasture, and provided technical reference for the development of grassland irrigation in the arid desert region.