Application of Phage Display Technology in Food Science: A review

doi:10.11924/j.issn.1000-6850.2014-0436

Abstract

Abstract: In this review, the application of phage display technology in food science was summarized. In the filed of food safety detection, phage display technology can be used as an efficient preparing method of antibody (or other affinity ligand) for the development of rapid immunoassay method, and used to screening epitope mimic peptide for the development of non-toxic detection technology. In the field of food processing, apart from used for detecting and removing the interfering substance, phage display technology can be used as a strategy for food enzyme direct evolution. In addition, this technology can also show its advantages in the field of food allergy, preparing food functional factors and developing novel food preservatives.

References

[1] Gao J, Wang Y, Liu Z, et al. Phage display and its application in vaccine design[J]. Annals of microbiology,2010,60(1):13-19.
[2] Li W, Caberoy N B. New perspective for phage display as an efficient and versatile technology of functional proteomics[J]. Applied microbiology and biotechnology,2010,85(4):909-919.
[3] Deutscher S L. Phage display in molecular imaging and diagnosis of cancer[J]. Chemical reviews,2010,110(5):3196-3211.
[4] 许达,黄小健,李春玲,等.噬菌体展示技术及其在动物病毒性疾病中的应用[J].中国畜牧兽医,2012,39(5):60-63.
[5] 陈敏,张志毅,卢孟柱.噬菌体展示技术及其在天牛防治中的应用展望[J].林业科学研究,2002,15(4):484-489.
[6] Wen S, Zhang X, Liu Y, et al. Selection of a single chain variable fragment antibody against ivermectin from a phage displayed library [J]. Journal of agricultural and food chemistry,2010,58(9):5387- 5391.
[7] 齐永华,董永军,宁红梅,等.单链抗体技术在农兽药残留检测方面的研究进展[J].东北农业大学学报,2011,42(9):7-12.
[8] Wang X, Zhang H, Liu H, et al. An immunoarray for the simultaneous detection of two mycotoxins, Ochratoxin A and Fumonisin B1[J]. Journal of Food Safety,2011,31(3):408-416.
[9] 张园园,裴世春,郑东和.噬菌体展示技术在食品真菌毒素检测领域的应用[J].中国农学通报,2008,24(3):87-90.
[10] Cho A, Shin K J, Chung J, et al. A sensitive enzyme immunoassay for amygdalin in food extracts using a recombinant antibody[J]. Journal of Food Protection,2008,71(10):2048-2052.
[11] Garet E, Cabado A G, Vieites J M, et al. Rapid isolation of singlechain antibodies by phage display technology directed against one of the most potent marine toxins: Palytoxin[J]. Toxicon,2010,55(8): 1519-1526.
[12] Lauer B, Ottleben I, Jacobsen H J, et al. Production of a singlechain variable fragment antibody against fumonisin B1[J]. Journal of agricultural and food chemistry,2005,53(4):899-904.
[13] Thie H, Voedisch B, Dübel S, et al. Affinity maturation by phage display[M]. Therapeutic Antibodies. Humana Press,2009:309-322.
[14] Guo Y C, Zhou Y F, Zhang X E, et al. Phage display mediated immuno-PCR[J]. Nucleic acids research,2006,34(8):62.
[15] Monecke S, Buechler J, Ehricht R. Measuring S. aureus exotoxin concentration using protein microarrays with antibodies generated by phage display[C]. Proceedings of the 21st European Congress of Clinical Microbiology and Infectious Diseases,2011:7-10.
[16] Jiang H, Fan M T. Multi- analyte immunoassay for pesticides: a review[J]. Analytical Letters,2012,45(11):1347-1364.
[17] Zhang H, Wang S, Fang G. Applications and recent developments of multianalyte simultaneous analysis by enzyme- linked immunosorbent assays[J]. Journal of immunological methods,2011, 368(1):1-23.
[18] Leivo J, Chappuis C, Lamminm?ki U, et al. Engineering of a broadspecificity antibody: detection of eight fluoroquinolone antibiotics simultaneously[J]. Analytical biochemistry,2011,409(1):14-21.
[19] Wen K, N?lke G, Schillberg S, et al. Improved fluoroquinolone detection in ELISA through engineering of a broad-specific singlechain variable fragment binding simultaneously to 20 fluoroquinolones[J]. Analytical and bioanalytical chemistry,2012, 403(9):2771-2783.
[20] Fan M, He J. Recent progress in noncompetitive hapten immunoassays: A review[M]. Trends in Immunolabelled and Related Techniques. InTech,2012:53-66.
[21] Niwa T, Kobayashi T, Sun P, et al. An enzyme- linked immunometric assay for cortisol based on idiotype–anti-idiotype reactions[J]. Analytica chimica acta,2009,638(1):94-100.
[22] 贺江,樊明涛,梁颖,等.抗独特型抗体在小分子物质免疫检测中的应用[J].分析化学,2010,38(9):1366-1370.
[23] 贺江,梁颖,樊明涛,等.噬菌体展示技术制备甲氧基有机磷农药抗独特型抗体[J].分析化学,2011,39(2):178-182.
[24] Kim H J, Rossotti M A, Ahn K C, et al. Development of a noncompetitive phage anti- immunocomplex assay for brominated diphenyl ether 47[J]. Analytical biochemistry,2010,401(1):38-46.
[25] Rossotti M A, Carlomagno M, Gonzalez- Techera A, et al. Phage anti- immunocomplex assay for clomazone: two- site recognition increasing assay specificity and facilitating adaptation into an onsite format[J]. Analytical chemistry,2010,82(21):8838-8843.
[26] Ihara M, Suzuki T, Kobayashi N, et al. Open- sandwich enzyme immunoassay for one- step noncompetitive detection of corticosteroid 11- deoxycortisol[J]. Analytical chemistry,2009,81 (20):8298-8304.
[27] Hara Y, Dong J, Ueda H. Open- sandwich immunoassay for sensitive and broad-range detection of a shellfish toxin gonyautoxin [J]. Analytica chimica acta,2013,793:107-113.
[28] Gebauer M, Skerra A. Anticalins: small engineered binding proteins based on the lipocalin scaffold[J]. Methods in enzymology,2012, 503:157-188.
[29] 杨金易,王弘,潘科,等.小分子化合物高特异性识别体制备新技术[J].食品科学,2007,28(1):366-369.
[30] Lavilla M, De Luis R, Pérez M D, et al. Selection of high affine peptide ligands for detection of Clostridium Tyrobutyricum spores [J]. Journal of microbiological methods,2009,79(2): 214-219.
[31] Morton J, Karoonuthaisiri N, Stewart L D, et al. Production and evaluation of the utility of novel phage display- derived peptide ligands to Salmonella spp. for magnetic separation[J]. Journal of applied microbiology,2013,115(1):271-281
[32] Wang J, Liu Z, Li G, et al. Simultaneous development of both competitive and noncompetitive immunoassays for 2, 2′ , 4, 4′- tetrabromodiphenyl ether using phage- displayed peptides[J]. Analytical and bioanalytical chemistry, 2013, 405(29): 9579-9583.
[33] González-Techera A, Vanrell L, Last J A, et al. Phage anti-immune complex assay: general strategy for noncompetitive immunodetection of small molecules[J]. Analytical chemistry,2007, 79(20):7799-7806.
[34] Kim H J, Ahn K C, González- Techera A, et al. Magnetic beadbased phage anti-immunocomplex assay (PHAIA) for the detection of the urinary biomarker 3- phenoxybenzoic acid to assess human exposure to pyrethroid insecticides[J]. Analytical biochemistry,2009, 386(1):45-52.
[35] González-Techera A, Kim H J, Gee S J, et al. Polyclonal antibodybased noncompetitive immunoassay for small analytes developed with short peptide loops isolated from phage libraries[J]. Analytical chemistry,2007,79(23):9191-9196.
[36] 武婕,杨金易,张宏斌,等.Lipocalin文库的构建及与克百威有结合活性的小分子筛选[J].高等学校化学学报,2008,29(3):528-532.
[37] Negi S S, Braun W. Automated detection of conformational epitopes using phage display peptide sequences[J]. Bioinformatics and biology insights,2009,3:71-81.
[38] Yang X, Yu X. An introduction to epitope prediction methods and software[J]. Reviews in medical virology,2009,19(2):77-96.
[39] Liu R, Xu L, Qiu X, et al. An Immunoassay for determining aflatoxin B1 using a recombinant phage as a nontoxic coating conjugate[J]. Journal of Food Safety,2012,32(3):318-325.
[40] Lai W, Fung D Y C, Yang X, et al. Development of a colloidal gold strip for rapid detection of ochratoxin A with mimotope peptide[J]. Food Control,2009,20(9):791-795.
[41] Liu R, Yu Z, He Q, et al. An immunoassay for ochratoxin A without the mycotoxin[J]. Food control, 2007,18(7):872-877.
[42] Liu X, Xu Y, He Q H, et al. Application of mimotope peptides of fumonisin b1 in Peptide ELISA[J]. Journal of agricultural and food chemistry,2013,61(20):4765-4770.
[43] He Q H, Xu Y, Huang Y H, et al. Phage- displayed peptides that mimic zearalenone and its application in immunoassay[J]. Food Chemistry,2011,126(3):1312-1315.
[44] Fernandez-Gacio A, Uguen M, Fastrez J. Phage display as a tool for the directed evolution of enzymes[J]. Trends in biotechnology,2003, 21(9):408-414.
[45] Verhaert R, Beekwilder J, Olsthoorn R, et al. Phage display selects for amylases with improved low pH starch- binding[J]. Journal of biotechnology,2002,96(1):103-118.
[46] 梁达奉,曾练强,郭亭,等.葡聚糖对制糖工业的影响及对策(上)[J].甘蔗糖业,2008,3:28-33.
[47] Kim D W, Day D F. Determination of dextran in raw sugar process streams[J]. Food Science and Biotechnology,2004,13:248-252.
[48] Kim D, Kim S R, Day D F, et al. A dipstick method to measure dextran in raw sugar process streams[J]. International sugar journal, 2009,111(1322):119-124.
[49] Jylh? S, M?kinen- Kiljunen S, Haahtela T, et al. Selection of recombinant IgE antibodies binding the β-lactoglobulin allergen in a conformation- dependent manner[J]. Journal of immunological methods,2009,350(1):63-70.
[50] Weichel M, Vergoossen N J, Bonomi S, et al. Screening the allergenic repertoires of wheat and maize with sera from doubleblind, placebo- controlled food challenge positive patients[J]. Allergy,2006,61(1):128-135.
[51] Hoffmann-Sommergruber K, Mills E N, Vieths S. Coordinated and standardized production, purification and characterization of natural and recombinant food allergens to establish a food allergen library [J]. Molecular nutrition & food research,2008,52(S2):S159-S165.
[52] Steckelbroeck S, Ballmer- Weber B K, Vieths S. Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes[J]. Journal of Allergy and Clinical Immunology,2008,121(6):1323-1330.
[53] Valenta R, Niederberger V. Recombinant allergens for immunotherapy[J]. Journal of allergy and clinical immunology, 2007,119(4):826-830.
[54] Codreanu F, Collignon O, Roitel O, et al. A novel immunoassay using recombinant allergens simplifies peanut allergy diagnosis[J]. International archives of allergy and immunology,2010,154(3):216- 226.
[55] 武涌,李欣,陈红兵,等.食物过敏原表位定位技术的研究进展[J].食品科学,2010,31(23):406-410.
[56] 何圣发,陈红兵,武涌,等.食物过敏原构象性表位预测技术研究进展[J].食品科学,2013,34(13):314-318.
[57] Tordesillas L, Pacios L F, Palacin A, et al. Molecular basis of allergen cross- reactivity: non- specific lipid transfer proteins from wheat flour and peach fruit as models[J]. Molecular immunology, 2009,47(2):534-540.
[58] Mittag D, Batori V, Neudecker P, et al. A novel approach for investigation of specific and cross-reactive IgE epitopes on Bet v 1 and homologous food allergens in individual patients[J]. Molecular immunology,2006,43(3):268-278.
[59] Davies J M, O’ Hehir R E, Suphioglu C. Use of phage display technology to investigate allergen- antibody interactions[J]. Journal of allergy and clinical immunology,2000,105(6):1085-1092.
[60] Sidhu S S. Phage display in pharmaceutical biotechnology[J]. Current opinion in biotechnology,2000,11(6):610-616.
[61] Huang L, Sexton D J, Skogerson K, et al. Novel peptide inhibitors of angiotensin- converting enzyme 2[J]. Journal of Biological Chemistry,2003,278(18):15532-15540.
[62] Kumada Y, Hashimoto N, Hasan F, et al. Screening of ACEinhibitory peptides from a random peptide-displayed phage library using ACE- coupled liposomes[J]. Journal of biotechnology,2007, 131(2):144-149.
[63] 李家大,王克夷.从噬菌体多肽文库中筛选α-葡萄糖苷酶的抑制剂[J].生物化学与生物物理学报,2001,33(5):513-518.
[64] Noppe W, Plieva F M, Vanhoorelbeke K, et al. Macroporous monolithic gels, cryogels, with immobilized phages from phagedisplay library as a new platform for fast development of affinity adsorbent capable of target capture from crude feeds[J]. Journal of biotechnology,2007,131(3):293-299.
[65] Fiedler E, Fiedler M, Proetzel G, et al. AffilinTM Molecules: Novel Ligands for Bioseparation[J]. Food and bioproducts processing, 2006,84(1):3-8.
[66] Noppe W, Plieva F M, Galaev I Y, et al. Immobilised peptide displaying phages as affinity ligands: Purification of lactoferrin from defatted milk[J]. Journal of Chromatography A,2006,1101(1): 79-85.
[67] Sato A K, Sexton D J, Morganelli L A, et al. Development of mammalian serum albumin affinity purification media by peptide phage display[J]. Biotechnology progress,2002,18(2):182-192.
[68] Molek P, Strukelj B, Bratkovic T. Peptide phage display as a tool for drug discovery: targeting membrane receptors[J]. Molecules, 2011,16(1):857-887.
[69] Rao S S, Mohan K V K, Atreya C D. A peptide derived from phage display library exhibits antibacterial activity against E. coli and Pseudomonas aeruginosa[J]. PloS one,2013,8(2):e56081.
[70] Bishop- Hurley S L, Rea P J, McSweeney C S. Phage- displayed peptides selected for binding to Campylobacter jejuni are antimicrobial[J]. Protein Engineering Design and Selection,2010,23 (10):751-757.
[71] Lai K N. Screening and isolation of antibacterial peptide against Klebsiella pneumoniae using 12- mer phage- displayed peptide library [D]. UTAR, 2013.
[72] Bratkovi? T, Lunder M, Urleb U, et al. Peptide inhibitors of MurD and MurE, essential enzymes of bacterial cell wall biosynthesis[J]. Journal of basic microbiology,2008,48(3):202-206.
[73] Paradis- Bleau C, Lloyd A, Sanschagrin F, et al. Phage displayderived inhibitor of the essential cell wall biosynthesis enzyme MurF[J]. BMC biochemistry,2008,9(1):33.
[74] Paradis- Bleau C, Beaumont M, Boudreault L, et al. Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme[J]. Peptides,2006,27(7):1693-1700.
[75] Liu S P, Zhou L, Lakshminarayanan R, et al. Multivalent antimicrobial peptides as therapeutics: design principles and structural diversities[J]. International journal of peptide research and therapeutics,2010,16(3):199-213.
[76] Bratkovi? T. Progress in phage display: evolution of the technique and its applications[J]. Cellular and molecular life sciences,2010,67 (5):749-767.