Abstract: The research was focused on the leaching of epoxiconazole in yellow soil, paddy soil and lime soil in Guizhou, aimed to provide data support for environmental risk of epoxiconazole. The thin layer chromatography method was used to study the leaching of epoxiconazole in 3 different soils in Guizhou, to evaluate the mobility and carry out risk assessment. The results showed that the moving distances of epoxiconazole in 3 different soils in Guizhou all were in the range of 0-3 cm, and their Rf value were 0.08. Epoxiconazole was not easily mobile in yellow soil, paddy soil and lime soil in Guizhou, and difficult to cause groundwater contamination through leaching into groundwater. But epoxiconazole was relatively easy to be absorbed in the soil and might result in certain risks to the soil environment.