Abstract: The quality of flue-cured tobacco is closely related to the quality of cigarette products and farmers’ economic benefit in planting tobacco, as variety is the foundation of flue-cured tobacco production, so it is important to explore the ways of improving the quality of flue-cured tobacco in China in view of varieties. In this paper, the evaluation criteria for the quality of flue-cured tobacco and the influencing factors were summed up on the basis of literatures of domestic scholars, and the effects of varieties on the quality of flue-cured tobacco were analyzed combined with the actual situation of tobacco production and breeding experience. It was supposed that the evaluation on the flue-cured tobacco quality should be combined with the specific demands of cigarette industries for the quality of tobacco leaves, and concerning a particular ecological environment, the variety was the most important factor among many factors which affected the quality of flue-cured tobacco. The effect of varieties on the quality of flue-cured tobacco included the genetic background of varieties which determined the quality of tobacco leaves, the interaction of varieties and ecological conditions which strengthened the quality of tobacco leaves, the anti-adversity and resistance of varieties which ensured the quality of tobacco leaves, and the harmony of varieties with production technologies which enhanced the quality of tobacco leaves. Accordingly, the paper put forward the ways to improve the quality of flue-cured tobacco in China in view of varieties, including: (1) to carry out the breeding aiming at the practical requirement of flue-cured tobacco production; (2) to make a rational distribution of flue-cured tobacco varieties and select the optimum variety for the suitable area,(3) to develop suitable planting technique for good varieties according to their characteristics.