Abstract: The study aims to change the traditional fertilization methods and cultivation mode of potato cultivation in Tibet, give play to the good habits and characteristics of virus free potato, improve potato yield and quality, and lay a foundation for the promotion of virus-free potato and development of potato industry. Using the orthogonal test method, under drought natural semiarid climatic of alpine region and poor soil conditions, the author studied high fertilization techniques of virus free potato and reasonable planting density. The results showed that nitrogen fertilizer could greatly promote the growth of potato plants and was one of the basic fertilizer to obtain high yield. Plenty of potassium fertilizer could be beneficial to the potato plant vegetative growth, yield and quality. When density was 90000 plants per hundred-square-meter, nitrogen fertilizer was 360 kg/hm², phosphate fertilizer was 180 kg/hm², potassium fertilizer was 300 kg/hm², the maximum yield of 35808 kg/hm² was achieved. The planting density increase could reduce the production of commodity potato, when sowing density was 75000 plants per hundred-square-meter, both the output and the increase production of commodity potato could be guaranteed. The study showed that in the alpine region within a certain range, the more the sowing density the higher the yield of the virus-free potato, nitrogen and potassium fertilizer belonged to the second influencing factor and phosphate fertilizer had no significant effect on yield.