Abstract: The paper aims to explore the best arranging model for drip irrigation belt under mechanical harvest of cotton in Xinjiang. The authors took Xinluzao No. 61variety as the experiment material, a field experiment under mechanical harvest model (plantation spacing 10 cm 66 cm 10 cm) was designed using different drip irrigation methods (6 cotton rows with 2 dripping pipes and 6 cotton rows with 3 dripping pipes under a plastic film mulching plantation pattern), plant growth and yield were observed. The results showed that, under 6 cotton rows with 2 dripping pipes, the growth of side-line cotton was slow, and the seedling rate and the growth rate of the side-line cotton were significantly lower than that of in-line cotton. Under 6 cotton rows with 3 dripping pipes, the growth of side-line cotton and in-line cotton was uniform, the growth difference was small. The yield and benefit of 6 cotton rows with 3 dripping pipes were significantly higher than that of 6 cotton rows with 2 dripping pipes. The yield and benefit of the former were 255 kg/hm2 and 1500 yuan/hm2 higher than that of the latter. Therefore, the 6 cotton rows with 3 dripping pipes under a plastic film mulching plantation pattern should be promoted.