Abstract: Studying the mechanism of optimal irrigation, fertilization management and atmospheric CO2 concentration of winter wheat is important to food security and agricultural sustainability. This paper simulated the impact of meteorological condition on the anthesis and maturity period of winter wheat during 2001 to 2010 based on the CERES-Wheat model in DSSATv4.5. The impact of irrigation and fertilization on winter wheat yield was studied by 42 kinds of compound modes and the optimal compound mode of irrigation and fertilization management was chosen. The winter wheat yield in different CO2-concentration conditions was simulated under the optimal irrigation and fertilization management. The results showed that the anthesis and maturity period of winter wheat advanced as the precipitation and mean temperature in growing season increased. The winter wheat yield increased and then stayed stable with the increase of irrigation and fertilizer amount, but excessive irrigation and fertilization would decrease the yield. The increase of atmospheric CO2 concentration had an obviously yield-increasing effect on winter wheat, and other production indexes showed a steady increase trend. The years whose mean temperature was less than 11.0℃ had later anthesis and maturity period; the compound mode of 300 kg/hm2 fertilization amount and 200 mm irrigation amount could achieve the ideal effect of winter wheat yield; the increase atmospheric CO2 concentration in the future 40 years could bring significantly yield-increasing effect on winter wheat.