Abstract: A pot experiment indicates that the promotion influences were found on the yield and quality by spraying different calcium fertilizers during the earlier stage, and that yield and quality were raised. The effect of 0.5%Ca (NO3)2 was significant. The increasing of plant high, leaf area, stem width and length, single gross weight and stem weight, and the reduction of nitrate content and the raising of vitamin C and solubility sugar content etc. were obvious found by sprayed 0.5%Ca (NO3)2. The sprayed 0.5%CaSO4 is slightly good on the increasing of lettuce stem width and single stem weight, and it is not significant to single gross weight, but is significant to the Vitamin C and the solubility sugar content of leaf. The effects of sprayed 0.5%CaCl2 on the lettuce yield increasing chiefly depended on promoting lettuce’s stretching and the growth of leaves. At the same time, the reduction of nitrate content in the lettuce stem and leaf, and the increasing of Vc content in the stem were significant by the 0.5%CaCl2 spraying.