Abstract: The yield of upper leaves of flue-cured tobacco accounts for 1/3 of the whole tobacco plant. In general, upper leaves of flue-cured tobacco, if they are well ripe, can produce high concentration smoke gas, high quantity aroma and a little irritating smog when they are burned. This kind of upper leaves would become the main raw material for the cigarette industry, significantly increasing the industrial usability and greatly improving cigarette raw material supplying structure. In this paper, the main ecological conditions for the sustainable development of tobacco production area in Chenzhou were analyzed, including the climatic characteristics, main climatic factors and climatic adaptability. The cultivation technical measures for the sustainable development of flue- cured tobacco production were discussed. The problems, such as early flowering, continuous cropping obstacle, and unreal mature forced by high temperature, low mature degree, which affected usability of upper leaves of flue cured tobacco in Chenzhou, were given a general review. The measures to improve the industrial usability of upper leaves were put forward.