Abstract: To compare the effects of loss control (WC) and normal compound fertilizer (NC) on the growth and development and yield of wheat, a random block experiment was set at the experimental field of Baoding Academy of Agricultural Science during 2015-2016. Winter wheat variety‘Baomai 10’was used as material, two kinds of fertilizers with the same nutrition content of N 20%，P2O5 20% and K2O 8% were applied at a rate of 600 kg/hm2 in soil preparation before sowing, 3 repeats were conducted. The results showed that there were significant differences in growth and development, dry matter accumulation and yield characteristics with different fertilizer treatments, and the effect of WC treatment was significantly better than that of NC treatment. Compared with NC, the 1000-grain weight, dry mass and yield of wheat could be increased by 2.5%, 20.7% and 6.3% respectively with WC treatment. LAI and photosynthetic rate of wheat at grain filling stage were increased with WC treatment. At the same time, WC treatment also increased the basal internode thickness and bending force, and the fertilizer agronomy efficiency (AE) increased by 23.5%. As a new type of fertilizer, WC will play an important role in improving wheat yield, increasing fertilization efficiency and protecting the environment.