Abstract: This paper aims to find scientific methods to enhance the salt-tolerant ability of crops. Winter wheat and summer maize were planted in barrel. The effects of four kinds of organic fertilizers in different water conditions on the growth and development, physiology and biochemistry, and yield of winter wheat and summer maize with saline soil cultivation were studied. The application of organic fertilizers could improve the soil environment. The organic fertilizer‘Heyijia’had the best effect, it increased the total nitrogen, organic contents and total microbial amounts in soil by 8.4%, 16.7% and 55.8%, respectively. Under the high soil water content, leaf chlorophyll content of wheat and maize was increased by about 6.9% and 5.10% by applying organic fertilizer, and the highest increase of the biomass of wheat and maize was by 60.0% and 51.2%, respectively. Leaf photosynthesis of winter wheat was increased by up to 20.8% under the application of the organic fertilizers. The grains per spike, 1000 grain weight and yield of winter wheat increased by 44.4%, 24.9% and 61.9%, respectively. Those indexes were also enhanced in lower water content, but the amplification was not as obvious as that in high water content. The application of organic fertilizers benefited the growth of crops in high salt soils with higher water content. Nevertheless, adding some kinds of fertilizers which were rich in salts might increase the salt concentration of soil and cause damage to crops. Overall, adding organic fertilizer could achieve better effects under higher soil water content.