Abstract: In order to find out the influence of the seed coating on the cultivation of perilla, and to provide guidance for the large-scale and standardized planting techniques of perilla. The study used two kinds of low-toxicity seed coating to treat perilla seeds. The germination rate experiment was used to select the suitable agent and concentration for preilla. the Aikedun seed coating were selected and the adding dose were 16mL per kilogram of seeds. Then the growth potential, yield, quality and resistance were determined Under the seed coating treatment. The results showed that the seedling activity could be improved obviously, and the growth rate of the seedlings of Perilla was increased under the treatment. the seedling rate increased by 7.72% and 31.31% of two strains of perilla, respectively. The yield per mu increased by 33.31kg and 11.15kg, respectively. Under the seed coating treatment, The biomass per plant and yield component traits were increased, thedisease-resistance against rust and powdery mildew and root rot also has significantly increased. But they showed no significant effect on quality of Perilla. This study showed that the addition of 16mL per kilogram of seeds of Aikedun seed coating can effectively promote the growth of seedlings and increase crop yield. The seed coating can be used to the crop farming production of Perilla.